000			03482nam a22003255i 4500
999			_c76656 _d76656 _x1
001			76656
003			ES-MaUEC
005			20230207040233.0
007			cr nn 008mamaa
008			140819s2014 ja | s |||| 0|eng d
020			_a9784431550525
024	7		_a10.1007/978-4-431-55052-5 _2doi
040			_dES-MaUEC
050		4	_aQD415 _b.I865 2014
100	1		_aIto, Koreaki _eeditor literario _0Local _985877
245	1	0	_aRegulatory Nascent Polypeptides _cedited by Koreaki Ito.
260			_aTokyo _bSpringer International Publishing _c2014
300			_a1 recurso en línea (IX, 315 p.) _b75 ilustraciones, 62 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
520			_aThis book highlights a new paradigm of translation control by regulatory nascent polypeptides, which is integrated into cellular regulatory systems. Translation lies in the hub of the central dogma of biology, in which the genetic information in the forms of 4-letter sentences is translated into 20-letter sentences: sequences of amino acids that constitute proteins, the functional molecules of life. The process involves a huge number of chemical reactions as well as physical movements of the ribosome along a messenger RNA and takes, on average, tens of seconds in prokaryotes and a few minutes in eukaryotes. Detailed knowledge about the progression of translation, called "elongation", only recently started to accumulate. Newly synthesized and growing polypeptides, called nascent polypeptides, can interact with the intra-ribosomal conduit, called the ribosomal exit tunnel, when they have some specific amino acid sequences, called "an arrest sequence". Such interaction leads to a halt in the elongation reaction. Resulting stalling of the ribosome on messenger RNA can affect the secondary structure and/or localization of the message in the cell, consequently leading to biological outputs such as elevation or reduction of a gene product. This book provides a first collection of knowledge focused on regulatory nascent polypeptides, which have been studied recently using diverse organisms including bacteria, plants, and animals. Readers will be impressed by a new paradigm showing that proteins can function even during the course of their biosynthesis and that the ribosome, the "factory" of protein production, interacts with and inspects its products to adjust the speed of completion of each product. Moreover, regulatory nascent polypeptides can sense or monitor physiological states of the cell and modulate its ability to arrest translation. Living organisms use such intricate control mechanisms of translational speed to regulate gene expression. This book will be a useful addition for established scientists while inspiring students and young scientists to gain deeper insights into the processes of expression of genetic information.
650		7	_2embne _aBioquímica _9138639
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-4-431-55052-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12822747 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQD415 .I865 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11551951 _z06-04-17
988			_aEBSPRINGER
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _gja _h0