000			04330nam a22003495i 4500
999			_c76650 _d76650 _x1
001			76650
003			ES-MaUEC
005			20230202102155.0
007			cr nn 008mamaa
008			140213s2014 ja | s |||| 0|eng d
020			_a9784431547648
024	7		_a10.1007/978-4-431-54764-8 _2doi
040			_dES-MaUEC
050		4	_aRC366 _b.S264 2014
100	1		_aSango, Kazunori. _eeditor literario _985859 _0Local
245	1	0	_aSchwann Cell Development and Pathology _cedited by Kazunori Sango, Junji Yamauchi.
260			_aTokyo _bSpringer International Publishing _c2014
300			_a1 recurso en línea (X, 174 p.) _b39 ilustraciones, 22 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aForeword -- Preface -- 1 Introduction (Kazunori Sango and Junji Yamauchi) -- 2 Recent insights into molecular mechanisms that control growth factor receptor-mediated Schwann cell morphological changes during development (Yuki Miyamoto and Junji Yamauchi) -- 3 Membrane Skeleton in Schmidt-Lanterman Incisure in Schwann cells of Peripheral Nervous System (Nobuo Terada, Yurika Saitoh, Nobuhiko Ohno, and Shinichi Ohno) -- 4 Schwann cell-axon interactions: the molecular and metabolic link between Schwann cells and axons (Nobuhiko Ohno, Takashi Sakoh, Yurika Saitoh, Nobuo Terada, and Shinichi Ohno) -- 5 Schwann cell-dependent regulation of peripheral nerve injury and repair (Keiichiro Susuki ) -- 6 Charcot-Marie-Tooth disease (Toru Ogata) -- 7 Expression of the transthyretin gene in Schwann cells, and familial amyloidotic polyneuropathy-mediated neurodegeneration (Tatsufumi Murakami and Yoshihide Sunada) -- 8 Node of Ranvier disruption: a key pathophysiology in immune-mediated neuropathies (Keiichiro Susuki ) -- 9 Pathogenesis of diabetic neuropathy from the viewpoint of Schwann cell abnormalities (Koichi Kato, Eva L. Feldman, and Jiro Nakamura) -- 10 Spontaneously immortalized adult rodent Schwann cells as valuable tools for the study of peripheral nerve degeneration and regeneration (Kazunori Sango, Masami Tsukamoto, Kazunori Utsunomiya, and Kazuhiko Watabe) -- BM Index.
520			_aThis book presents recent topics on the development, differentiation, and myelination of Schwann cells, as well as pathological mechanisms and therapeutic approaches for peripheral neuropathies, such as Charcotâ€{uD872}ieâ€{u4BEF}th diseases, amyloid polyneuropathy, immune-mediated neuropathy, and diabetic neuropathy. The rapid progress of molecular biological techniques in the last decades, especially for RNA techniques and gene modification technologies, have allowed us to investigate the pathobiology of Schwann cells in vivo and in vitro. Studies combining recent stem cell biology with recent biotechnology, which is now closely linked to physicochemical fields, further explain how Schwann cell lineages develop, a process that has long been thought to be very complicated in vivo. The findings contribute to the elucidation of fundamental mechanisms during development and under pathological conditions. We now know that these are closely tied to each other. This book also introduces unique coculture systems to reproduce the neuronâ€{u38E8}wann cell interplay during development, degeneration, and regeneration. Up-to-date research topics with high-quality immunofluorescence and electron micrographs introduced by young and energetic contributors are sure to arouse the readers' interest in Schwann cell biology. Discussion from the viewpoint of basic and clinical neuroscience makes the book educational for researchers, medical students, and young clinicians.
650		7	_2embne _aSistema nervioso central _xEnfermedades _9188115
700	1		_aYamauchi, Junji _eeditor literario _985860 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-4-431-54764-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12822681 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aRC366 .S264 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11551896 _z06-04-17
988			_aEBSPRINGER
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _gja _h0