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008			130619s2013 ja | s |||| 0|eng d
020			_a9784431544098
024	7		_a10.1007/978-4-431-54409-8 _2doi
040			_bspa _dES-MaUEC
050		4	_aQR185.8.C95
082	0	4	_a572.6
100	1		_aMoustakas, Aristidis _eeditor literario _985839 _0Local
245	1	0	_aTGF-β in Human Disease _cedited by Aristidis Moustakas, Keiji Miyazawa.
260			_aTokyo _bSpringer International Publishing _c2013
300			_a1 recurso en línea (VIII, 464 p.) _b39 ilustraciones, 32 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aIntroduction. Transforming growth factor-[beta] signaling / Carl-Henrik Heldin -- TGF-[beta] signaling in stem cell fate determination / Zhongwei Li, Danny Huylebroeck, Ye-Guang Chen -- Emerging roles of TGF-[beta] co-receptors in human disease / Alison E. Meyer, Karthikeyan Mythreye, Gerard C. Blobe -- Cancer, fibrosis, and inflammation. TGF-[beta] in cancer stem cells / Hiroaki Ikushima, Kohei Miyazono -- TGF-[beta] as tumor suppressor: in vitro mechanistic aspects of growth inhibition / Laurent Bartholin, David F. Vincent, Ulrich Valcourt -- TGF-[beta] as tumor suppressor: lessons from mouse models / Ulrich Valcourt, David F. Vincent, Laurent Bartholin -- The multifunctional roles of TGF-[beta] in navigating the metastatic cascade / Michael K. Wendt, William P. Schiemann -- TGF-[beta] signaling in leukemogenesis / Kazuhito Naka, Atsushi Hirao -- TGF-[beta] in skin cancer and fibrosis / Gangwen Han, Zheyi Han, Xiao-Jing Wang -- The role of TGF-[beta] in cutaneous melanoma biology / Delphine Javelaud, Alain Mauviel -- The transforming growth factor-beta (TGF-[beta]) in liver fibrosis / Isabel Fabregat, Patricia Sancho -- TGF-[beta] and inhibitory smads in inflammation / Seong-Jin Kim, Seok Hee Park -- Cardiovascular diseases. TGF-[beta] and cardiovascular disorders / Laurens A. van Meeteren, Marie-José Goumans, Peter ten Dijke -- TGF-[beta] signaling in physiological and pathological angiogenesis / Sara I. Cunha, Kristian Pietras -- TGF-[beta] signaling pathway and micrornas in cardiovascular disease / Nisha Marathe, Akiko Hata -- Other diseases. TGF-[beta] and genetic skeletal diseases / Shiro Ikegawa, Mitsuko Nakashima, Naomichi Matsumoto -- TGF-[beta] in brain disorders / Kerstin Krieglstein -- TGF-[beta] and metabolic homeostasis / Grace Bennett, Sushil G. Rane -- Disease prognosis and therapy. Targeting pro-angiogenic TGF-[beta] signaling in the tumor microenvironment / Kristian Pietras, Sara I. Cunha
520			_aTransforming growth factor-[beta] (TGF-[beta]) is a secreted polypeptide with multifunctional properties manifested during embryonic development, adult organ physiology, and pathobiology of major diseases, including cancer and fibrotic and cardiovascular diseases. The signaling pathway of TGF-[beta] now is rather well understood. Continuing revelations in the mechanisms of action of TGF-[beta] provide specific mechanistic examples of how human cells lose their controlled function and behave wrongly during the development of diverse diseases. Equally important, however, is the current promise of exploiting the TGF-[beta] pathway in combating human disease. This book comprehensively covers major areas of human disease where the involvement of TGF-[beta] is firmly established. Simultaneously, the book highlights major gaps in knowledge and the future directions of research that can benefit human medical science. The core set of diseases where TGF-[beta] action is well documented and are included in the book are cancer and cardiovascular and fibrotic disorders. The central aim of the book is to stimulate young scientists to enter the prolific TGF-[beta] field and find new solutions to the problems remaining in this area of study. For this purpose the book provides authoritative educational chapters that furnish a good introduction to the field for young doctoral students, postdocs, and clinical fellows. The book also serves as a valuable reference for the aficionados in the field, who can find accessible and well-illustrated material for their teaching and lecturing activities, via which the importance of TGF-[beta] biology is disseminated to the world of science and to the public.
650		7	_aCitoquinas _0LocalV _2embne _9147650
650		7	_aCitología _0LocalV _2embne _9139477
650	2	7	_aCitología _0LocalV _2embne _9139477
650		7	_aCáncer _xInvestigación _0comprobar BNE19901364217 _2embne _9182523
650		0	_9495993 _aCiencias de la vida _0LocalV
650		7	_aOncología _0LocalV _2embne _9139207
700	1		_aMiyazawa, Keiji _eeditor literario _985840 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-4-431-54409-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12822590 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQR185.8.C95 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i1155180x _z06-04-17
988			_aEBOOK, EBSPRINGERrevisando
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _gja _h0