000			05232nam a22003615i 4500
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003			ES-MaUEC
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007			cr nn 008mamaa
008			100301s2006 ja | s |||| 0|eng d
020			_a9784431342007
024	7		_a10.1007/4-431-34200-1 _2doi
040			_dES-MaUEC
050		4	_aQP752.S6 _bH573 2006
100	1		_aHirabayashi, Yoshio _eeditor literario _0Local _985795
245	1	0	_aSphingolipid Biology _cedited by Yoshio Hirabayashi, Yasuyuki Igarashi, Alfred H. Merrill.
260			_aTokyo _bSpringer International Publishing _c2006
300			_a1 recurso en línea (XXVI, 531 p.) :
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aOverview -- Sphingolipids Synthesis, Transport and Cellular Signaling -- Biosynthesis, Transport of Sphingolipids -- Serine Palmitoyltransferase -- Ceramide Synthase -- Dihydroceramide: Sphinganine ?4-Desaturase and C4-Hydroxylase -- Metabolizing Enzymes Such As Sphingomyelin Synthase Induce Cell Death by Increasing Ceramide Content -- Glucosylceramide and Galactosylceramide Synthase -- Synthesis, Metabolism, and Trans-Bilayer Movement of Long-Chain Base -- Molecular Mechanism of Ceramide Trafficking from the Endoplasmic Reticulum to the Golgi Apparatus in Mammalian Cells -- Sphingolipid Trafficking -- Current Perspectives on Saccharomyces cerevisiae Sphingolipids -- Generation and Degradation of Sphingolipid Signaling Molecules -- Generation of Signaling Molecules by De Novo Sphingolipid Synthesis -- Overview of Acid and Neutral Sphingomyelinases in Cell Signaling -- Neutral Ceramidase as an Integral Modulator for the Generation of S1P and S1P-Mediated Signaling -- Activation of Sphingosine Kinase 1 -- Ceramide 1-Phosphate -- Sphingosine-1-Phosphate Lyase -- Membrane Domain and Biological Function -- Close Interrelationship of Sphingomyelinase and Caveolin in Triton X-100-lnsoluble Membrane Microdomains -- Roles of Membrane Domains in the Signaling Pathway for B Cell Survival -- The Role of Lipid Rafts in Axon Growth and Guidance -- Sphingolipids and Multidrug Resistance of Cancer Cells -- Membrane Lipid Domain and Human Pathobiology -- A New Pathological Feature of Insulin Resistance and Type 2 Diabetes: Involvement of Ganglioside GM3 and Membrane Microdomains -- Neuronal Cell Death in Glycosphingolipidoses -- Endocytic Trafficking of Glycosphingolipids in Sphingolipidoses -- Ganglioside and Alzheimerâ€{u3804}isease -- Modulation of Proteolytic Processing by Glycosphingolipids Generates Amyloid ?-Peptide -- Hereditary Sensory Neuropathy -- Ceramide, Ceramide Kinase and Vision Defects: A BLIND Spot for LIPIDS -- Fumonisin Inhibition of Ceramide Synthase: A Possible Risk Factor for Human Neural Tube Defects -- Sphingolipids and Cancer -- S1P Signaling and SIPR -- Sphingosine-1-Phosphate and the Regulation of Immune Cell Trafficking -- Sphingolipids and Lung Vascular Barrier Regulation -- Signaling Mechanisms for Positive and Negative Regulation of Cell Motility by Sphingosine-1-Phosphate Receptors -- Sphingosine 1-Phosphate-Related Metabolism in the Blood Vessel -- Advanced Technology in Sphingolipid Biology -- Conventional/Conditional Knockout Mice -- Biosynthesis and Function of Drosophila Glycosphingolipids -- Characterization of Genes Conferring Resistance Against ISP-1/Myriocin-Induced Sphingolipid Depletion in Yeast -- Lysenin: A New Probe for Sphingomyelin -- Structural Biology of Sphingolipid Synthesis -- A Computer Visualization Model for the De Novo Sphingolipid Biosynthetic Pathway.
520			_aSphingolipids are fundamental to the structures of cell membranes, lipoproteins, and the stratum cornea of the skin. Many complex sphingolipids as well as simpler sphingoid bases and derivatives are highly bioactive as extra- and intracellular regulators of growth, differentiation, migration, survival, senescence, and numerous cellular responses to stress. This book provides many examples of exciting new developments in sphingolipid biology/sphingolipidology that are changing our understanding of how multicellular organisms grow, develop, function, age, and die. Key areas addressed include sphingolipid biosynthesis, transport and membrane organization/lipid rafts; genetic approaches to understanding the roles of membrane sphingolipid biosynthesis; sphingolipid metabolism, specific G protein-coupled receptors (GPCRs), and signal transduction; and sphingolipid-associated disease and drug development.
650		7	_2embne _9138315 _aQuímica orgánica
700	1		_aIgarashi, Yasuyuki _eeditor literario _985796 _0Local
700	1		_aMerrill, Alfred H. _eeditor literario _0Local _985797
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/4-431-34200-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12822450 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQP752.S6 H573 2006 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11551665 _z06-04-17
988			_aEBSPRINGER
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _gja _h0