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008			100301s2006 sz | s |||| 0|eng d
020			_a9783764375430
024	7		_a10.1007/3-7643-7543-4 _2doi
040			_dES-MaUEC
050		4	_aQP96 _b.M655 2006
100	1		_aMolineux, Graham. _eeditor literario _985771 _0Local
245	1	0	_aErythropoietins and Erythropoiesis : _bMolecular, Cellular, Preclinical, and Clinical Biology _cedited by Graham Molineux, Mary Ann Foote, Steven G. Elliott.
260			_aBasel _bSpringer International Publishing _c2006
300			_a1 recurso en línea (X, 269 p.) :
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aMilestones in Drug Therapy MDT
505	0		_aBackground and basic science -- Erythropoiesis: an overview -- Studies of erythropoiesis and the discovery and cloning of recombinant human erythropoietin -- Structural basis for the signal transduction of erythropoietin -- Molecular biology of the erythropoietin receptor in hematopoietic and non-hematopoietic tissues -- Erythropoietin receptor signaling processes -- Clinical pharmacokinetic properties of rHuEPO: a review -- Biology of erythropoietin -- Commercial production of recombinant erythropoietins -- Clinical use of recombinant erythropoietins -- Use of recombinant erythropoietins in the setting of renal disease -- Erythropoietic therapy in the practice of oncology -- Use of recombinant erythropoietins for the treatment of anemia of chronic disease -- Use of erythropoietins in the surgical setting -- Abuse of recombinant erythropoietins by athletes -- Antibodies to endogenous and recombinant erythropoietin -- New molecules and formulations of recombinant human erythropoietin.
520			_aResearch on, and interest in, red blood cell formation spans several centuries and was thought to have peaked in the 1980s with the cloning of the eryth- poietin (EPO) gene. In the years subsequent to the cloning of EPO and its expression as a recombinant protein, much was written about EPO. Although much has been learned and published, new, exciting data are becoming ava- able on almost a daily basis. Erythropoietins and Erythropoiesis: Molecular, Cellular, Preclinical, and Clinical Biology compiles both pertinent historical and very recent research on this molecule and its clinical utility. The book is divided into two sections: Background and Basic Science and Clinical Uses of Recombinant Erythropoietins. To begin, Israels and Israels describe the biology of red cells, the hierarchy of erythropoietic progenitor cells, their development to mature cells, and the effects of endogenous EPO on their development. Foote summarizes the historical interest in, and search for, an erythropoietic factor. Once EPO was identified,cloned,and expressed,the path was set for the study of other aspects of EPO biology both within e- thropoiesis and other cellular systems.
650		7	_2embne _9160868 _aCélulas sanguíneas
700	1		_aFoote, Mary Ann _eeditor literario _985772 _0Local
700	1		_aElliott, Steven G. _eeditor literario _0Local _985773
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/3-7643-7543-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12822358 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQP96 .M655 2006 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11551562 _z06-04-17
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