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001			76610
003			ES-MaUEC
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007			cr nn 008mamaa
008			100301s2006 sz | s |||| 0|eng d
020			_a9783764374181
040			_aES-MaUEC
050		4	_aRC280.B8 _bA76 2006 EB
245	0	0	_aAromatase Inhibitors _cedited by Barrington J.A. Furr
260			_aBasel _bBirkhäuser _c2006
300			_a1 recurso en línea (IX, 182 p.) 30 il.
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aMilestones in Drug Therapy MDT
520			_aMany breast tumours are dependent upon oestrogen for their development and continued growth. Over the last 25 years hormone therapy has progressed from the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrogen synthesis or action. The inhibition of oestrogen synthesis is most readily achieved by inhibiting the final step in the pathway of oestrogen biosynthesis, the reaction which transforms androgens into oestrogens by creating an aromatic ring in the steroid molecule (hence the enzyme's trivial name, aromatase). Whereas the first aromatase inhibitors to be used therapeutically could be shown to produce drug-induced inhibition of the enzyme and therapeutic benefits in patients with breast cancer, they were not particularly potent and lacked specificity. However, second-generation drugs were developed and most recently third-generation inhibitors have evolved which possess remarkable specificity and potency. Initial results from clinical trials suggest that these agents will become the cornerstones of future endocrine therapy
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aMamas _xCáncer _0comprobar BNE19901364206 _2embne _9182522
700	1		_aFurr, Barrington J. A. _eeditor literario _0Local _985759
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/3-7643-7418-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783764374181
907			_a.b12822280 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b17-03-17 _cm _dz _ek _feng _gsz _h0
945			_aRC280.B8 A76 2006 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11551495 _z06-04-17
999			_c76610 _d76610 _x1