000			03381nam a22003615i 4500
988			_aEbook_one2one
999			_c76605 _d76605 _x1
001			76605
003			ES-MaUEC
005			20240611040132.0
007			cr nn 008mamaa
008			140922s2014 au | s |||| 0|eng d
020			_a9783709118061
024	7		_a10.1007/978-3-7091-1806-1 _2doi
040			_aES-MaUEC
050		4	_aQP552.G16 _bR37 2014 vol. 1 EB
082	0	4	_a571.6
245	0	0	_aRas Superfamily Small G Proteins : _bBiology and Mechanisms 1 : General Features, Signaling _cedited by Alfred Wittinghofer.
264		1	_aVienna _bSpringer International Publishing _c2014
300			_a1 recurso en línea (XIV, 445 páginas) _b85 ilustraciones, 83 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aEvolution of the Ras Superfamily of GTPases -- The structure of the G domain of the Ras superfamily -- GEFs and GAPs: Mechanisms and Structures -- Bacterial protein toxins acting on small GTPases -- Posttranslational modifications of small G proteins -- Targeting the Raf-MEK-ERK Mitogen-Activates Protein Kinase Cascade for the Treatment of RAS Mutant Cancers -- RAS Genes and Cancer -- The Spatial Organization of Ras Signaling -- Ras Nanoclusters -- Mouse Models of Ras induced Tumors and Developmental Disorders -- Rap signaling -- The coordinated biology and signaling partners of Ral G-proteins -- Structure and Function of the mTOR Activator Rheb -- Classical Rho proteins: Biochemistry of molecular switch function and regulation -- Atypical Rho family members -- Molecular Structures, Cellular Functions and Physiological Roles of Rho Effectors -- Principles driving the spatial organization of Rho GTPase signaling at synapses -- Rho GTPases in Cancer.
520			_aThis first of two volumes provides a general overview of the genetics, structure, mechanism and regulation of the Ras superfamily proteins and describes in detail the signaling pathways and processes regulated by specific members of this family. The focus of this first volume is on the Rho and Ras subfamily of small G proteins. Renowned scientists provide insights into the biochemistry of the classical and non-classical small G-protein family members, their spatio-temporal regulation, their effectors and their roles in health and disease. Together with Volume 2, this book provides a comprehensive and state-of-the-art work on small G-proteins (GTPases). It is intended for graduates and professors in biochemistry and cell biology already working on small G-proteins (small GTPases), but also offers an extremely valuable resource for those readers who are new to the field.
650		7	_aProteínas G _2embne _9147588
700	1		_aWittinghofer, Alfred. _eeditor literario. _985240 _0Local _1http://viaf.org/viaf/232253482
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-7091-1806-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12822231 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQH573-671 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11551446 _z06-04-17
988	0	0	_aEBOOK, EBSPRINGER, GOBI_sep2018
998			_aSI _a_alco _a_vill _b10/2018 _cm _dz _ef _feng _gau _h0