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008			140723s2014 au | s |||| 0|eng d
020			_a9783709117880
040			_aES-MaUEC
050		4	_aQH581.2 _bB763 2014 EB
082	0	4	_a571.6
245	0	0	_aMolecular Machines Involved in Peroxisome Biogenesis and Maintenance _cedited by Cecile Brocard, Andreas Hartig
260			_aVienna _bSpringer International Publishing _c2014
300			_a1 recurso en línea (XV, 543 p.) _b51 il.
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aPeroxisome biogenesis and function: History and Discovery of peroxins.- Human cell lines to study peroxisome biogenesis.- Mouse models to study peroxisome biogenesis.- Metabolic interaction between peroxisome and Mitochondria.- Peroxisomal Diseases:The Zellweger spectrum.- Molecular basis.- PEX11beta.- Peroxisome morphology in pathologies.- Other peroxisome-related disorders.- New technologies applied to study peroxisomes: Bioinformatics.- Imaging in plant and peroxules.- Tools to study peroxisomes as signaling platform: oxidative stress studies and antiviral innate immunity.- Proteomic approach. Protein transport across the peroxisomal membrane: The matrix protein import complex in yeast.- Protein transport in plant peroxisomes.- Concept Exportomer.- Factors involved in ubiquitination/deubiquitination of PEX5.- Peroxisome dynamics: Trafficking of the peroxisome biogenesis factor PEX3 through the ER.- Role of PEX3 and PEX19 in peroxisome membrane biogenesis.- Vesicles, reticulon and ER-to-peroxisome contact sites.- Pex11 proteins and their alpha-helix.- Molecular complex coordinating peroxisome morphogenesis.- Dynamin-related proteins. Specific degradation through pexophagy: Principle of selective organelle degradation: Factors involved in pexophagy in the yeast Pichia pastoris.
520			_aIn eukaryotes, lipid metabolism requires the function of peroxisomes. These multitasking organelles are also part of species-specific pathways such as the glyoxylate cycle in yeast and plants or the synthesis of ether lipid in mammals. Proteins required for the biogenesis of peroxisomes typically assemble in large molecular complexes, which participate in membrane formation, protein transport, peroxisome duplication and - inheritance during cell division. Peroxisomal function is essential for life. Mutations in PEX genes, encoding for biogenesis factors, are often associated with lethal disorders. The association of peroxisomes with other organelles suggests an extensive participation in organellar crosstalk. This book represents a state-of-the-art review in the field of peroxisome research encompassing the cell and molecular biology of peroxisome biogenesis and its diseases, the protein complexes involved in this process and the modern technologies applied to study them. The book is intended for graduate students, researchers and lecturers in biochemistry, molecular and cell biology with a biomedical background.
650		7	_aCitología _9139477 _2embne
650		7	_aMembranas celulares _9142266 _2embne
700	1		_aBrocard, Cecile _eeditor literario _0Local _985750
700	1		_aHartig, Andreas _eeditor literario _985751 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-7091-1788-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783709117880
907			_a.b1282222x _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQH603 .P47 B763 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11551434 _z06-04-17
988			_aEBOOK, EBSPRINGERrevisando
998			_am _a_alco _a_vill _b05-07-17 _cm _dz _ef _feng _gau _h0