000			03360nam a22003375i 4500
999			_c76597 _d76597 _x1
001			76597
003			ES-MaUEC
005			20230202102139.0
007			cr nn 008mamaa
008			130902s2013 au | s |||| 0|eng d
020			_a9783709115503
024	7		_a10.1007/978-3-7091-1550-3 _2doi
040			_dES-MaUEC
050		4	_aRA1247.H8 _bK568 2013
100	1		_aKimura, Hideo. _eeditor literario _985739 _0Local
245	1	0	_aHydrogen Sulfide and its Therapeutic Applications _cedited by Hideo Kimura.
260			_aVienna _bSpringer International Publishing _c2013
300			_a1 recurso en línea (IX, 207 p.) _b39 ilustraciones, 23 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aBiogenesis and Catabolism of Hydrogen Sulfide -- Multiple roles of H2S in inflammation â€{u0860}new class of therapeutics? -- Hydrogen Sulfide and Oxygen Sensing -- The signal transduction of H2S: identification of the â€r̃eceptorâ€{u09AF}r H2S -- Hydrogen sulfide: Physiological and pathophysiological functions -- Therapeutic Applications of Hydrogen Sulfide -- Biological effects of H2S inhalation and its therapeutic potential -- H2S-mediated defense against antibiotics in bacteria -- Modulation of cellular signaling and induction of cytoprotection by hydrogen sulfide.
520			_aThe metabolism of sulfur especially by sulfurtransferases had been intensively studied in mid 1900â€{u3B82}{u0528}ree enzymes, cystathionine βâ€{u3E6E}thase (CBS), cystathionine γâ€{uCE61}se (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST) were found to have the capacity to produce H2S in vitro.Âȯwever, H2S was recognized simply as a by-product of the metabolic pathways or as a marker for evaluating the activity of enzymes rather than as a physiological active molecule.Â{u2820} In the late 1980â€{u3832}elatively high concentrations of sulfide were measured in the brain that led to the successive studies of identifying the physiological functions of H2S. Â{u2963}ently, the steady-state concentrations of H2S have been re-evaluated and found to be much less than that initially measured.Âȯwever, despite these differences, such re-evaluations served to further confirm the existence of H2S in mammalian tissues.Â{u0232}S is produced in almost every organ and plays various roles such as neuromodulation, vasodilation, insulin release, inflammation, angiogenesis and cytoprotection. The unregulated production of H2S and improper responses of target molecules are involved in the pathogenesis of various diseases.This book focuses on these topics as well as on the recent progress in the biology and the therapeutic development of this molecule.
650		7	_2embne _9360400 _aGases asfixiantes y venenosos _xToxicidad
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-7091-1550-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12822152 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aRA1247.H8 K568 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11551367 _z06-04-17
988			_aEBSPRINGER
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _gau _h0