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008			140121s2013 au | s |||| 0|eng d
020			_a9783709108857
024	7		_a10.1007/978-3-7091-0885-7 _2doi
050		4	_aQP609.P78 _bP76 2013 EB
082	0	4	_a572.6
245	0	0	_aProteases : _bStructure and Function _cedited by Klaudia Brix, Walter StÃœcker
260			_aVienna _bSpringer International Publishing _c2013
300			_a1 recurso en línea (XII, 564 p.) _b98 ilustraciones, 65 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_a1 Protease families, evolution and mechanisms of action "Set the stage" -- 1.1 Enzyme families, prototypes and catalytic mechanisms -- 1.2 Enzyme kinetics, mathematical modelling and perspectives -- 1.3 Structure determination and search for inhibitors -- 2 Regulation of proteolysis "Positioning and teaming-up to control activity" -- 2.1 Compartmentalization of proteolysis -- 2.2 Biosynthesis of lysosomal proteases -- 2.3 Interactions of proteases and inhibitors / networking in the degradome -- 2.4 In vivo analysis of the protease and inhibitors concert -- 3 Proteases in development "Born to be right" -- 3.1 Proteases for pattern formation during morphogenesis -- 3.2 Proteases in death pathways (apoptosis, necrosis) -- 4 Proteases in physiology and pathophysiology Cleave to function in health or to cause disease" -- 4.1 Protein turnover and signaling functions (degrade to rebuild, remodel, process and mature for signalling) -- 4.2 Proteases in control of physiology -- 4.3 Cancer: invasion and metastasis -- 4.4 Bacterial proteases -- 4.5 Viral proteases
520			_aProteolysis is an irreversible posttranslational modification affecting each and every protein from its biosynthesis to its degradation. Limited proteolysis regulates targeting and activity throughout the lifetime of proteins. Balancing proteolysis is therefore crucial for physiological homeostasis. Control mechanisms include proteolytic maturation of zymogens resulting in active proteases and the shut down of proteolysis by counteracting endogenous protease inhibitors. Beyond the protein level, proteolytic enzymes are involved in key decisions during development that determine life and death from single cells to adult individuals. In particular, we are becoming aware of the subtle role that proteases play in signaling events within proteolysis networks, in which the enzymes act synergistically and form alliances in a web-like fashion. Proteases come in different flavors. At least five families of mechanistically distinct enzymes and even more inhibitor families are known to date, many family members are still to be studied in detail. We have learned a lot about the diversity of the about 600 proteases in the human genome and begin to understand their physiological roles in the degradome. However, there are still many open questions regarding their actions in pathophysiology. It is in this area where the development of small molecule inhibitors as therapeutic agents is extremely promising. Approaching proteolysis as the most important, irreversible post-translational protein modification essentially requires an integrated effort of complementary research disciplines. In fact, proteolytic enzymes seem as diverse as the scientists working with these intriguing proteins. This book reflects the efforts of many in this exciting field of research where team and network formations are essential to move ahead
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aEnzimas proteolíticas _9146220 _0comprobar BNE19923137217 _2embne
700	1		_aBrix, Klaudia _eeditor literario _985715 _0Local
700	1		_aStÃœcker, Walter _eeditor literario _985716 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-7091-0885-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783709108857
907			_a.b12821986 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b31-07-17 _cm _dz _eb _feng _gau _h0
945			_aQP609 .P78 P76 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11551197 _z06-04-17
999			_c76580 _d76580 _x1