000			03854nam a22003855c 4500
001			76569
003			ES-MaUEC
005			20230202102129.0
007			cr nn 008mamaa
008			140904s2014 gw | s |||| 0|eng d
020			_a9783662436042
024	7		_a10.1007/978-3-662-43604-2 _2doi
050		4	_aRM262 _b.M48 2014 EB
082	0	4	_a615
245	0	0	_aMetronomic Chemotherapy : _bPharmacology and Clinical Applications _cedited by Guido Bocci, Giulio Francia
260			_aBerlin, Heidelberg _bSpringer International Publishing _c2014
300			_a1 recurso en línea (XVI, 295 p.) _b22 ilustraciones, 13 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aPart I: Pharmacological bases of metronomic chemotherapy: The metronomic concept -- Antiangiogenic effects of metronomic chemotherapy -- Effects of metronomic chemotherapy on immunity -- Other proposed mechanism of action of metronomic chemotherapy. Part II:Preclinical studies of metronomic chemotherapy: Alkylating agents -- Camptothecins -- Fluoropyrimidines -- Taxanes -- Vinca alkaloids -- Anthracyclines -- Other drugs -- Part III. Drugs combined with metronomic chemotherapy in preclinical studies: Tyrosine kinase inhibitors -- Monoclonal antibodies -- Tumor vaccines -- Other drugs. Part IV. Clinical activity of metronomic chemotherapy: Breast cancers -- Prostate cancers -- Gastrointestinal cancers -- CNS cancers -- Pediatric malignancies -- Sarcomas -- Hematological cancers -- Liver cancers -- GynecologicCancers -- Lung cancers -- Other cancers. Part V: Clinical Pharmacology of metronomic chemotherapy: Pharmacokinetics of metronomic chemotherapy -- Pharmacodynamics of metronomic chemotherapy -- Pharmacogenetics of metronomic chemotherapy -- Pharmacoeconomics of metronomic chemotherapy and its social impact -- Adverse drug reactionsof metronomic chemotherapy. Part VI: Metronomic chemotherapy in veterinarian clinic: Clinical studies of metronomic chemotherapy alone -- Clinical studies of metronomic chemotherapy and other drugs
520			_aThis book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoenconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aQuimioterapia _9138367 _0comprobar BNE19900958967 _2embne
650		7	_aCáncer _xTratamiento _9174085 _0comprobar BNE19901177073 _2embne
700	1		_aBocci, Guido _eeditor literario _985701 _0Local
700	1		_aFrancia, Giulio _eeditor literario _985702 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-662-43604-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_aocn9783662436042
907			_a.b12821871 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b31-07-17 _cm _dz _eb _feng _ggw _h0
945			_aRM262 .M48 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11551082 _z06-04-17
999			_c76569 _d76569 _x1