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001			76546
003			ES-MaUEC
005			20230207040229.0
007			cr nn 008mamaa
008			140312s2014 gw s 000 0 eng d
020			_a9783642451980
024	7		_a10.1007/978-3-642-45198-0 _2doi
040			_aES-MaUEC
050		4	_aQP91 _b.T73 2014 EB
082	0	4	_a611.01816
082	0	4	_a599.935
245	0	0	_aTranscriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development _cedited by Constanze Bonifer, Peter N. Cockerill
264		1	_aBerlin, Heidelberg _bSpringer International Publishing _c2014
300			_a1 recurso en línea (XIII, 416 p.) _b49 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aEpigenetics and Human Health _x2191-2262
505	0		_aPreface -- Introduction -- Non-mammalian hematopoiesis -- Epigenetic mechanisms regulating mammalian hematopoietic stem cell development and function -- Epigenetic and transcriptional mechanisms regulating cell fate decisions and blood cell lineage development -- Epigenetic control of immune cell function -- Subject index
520	3		_aIn recent years, great progress has been made in the identification of the molecular players involved in the epigenetic control of gene expression during development. The work of many laboratories has established that regulating the interplay of transcription factors with chromatin components is the major driver of cellular differentiation. Because of their single cell nature and ease of purification, much of what we have learnt about these processes in animals has been delivered based on cellular models within the hematopoietic system. The blood cell system evolved from a few simple cell types in more primitive organisms that provide oxygen transport and carry out phagocytosis into the complex hematopoietic system of mammals, containing many specialized cells types with vastly different functions, such as B cells, T cells, granulocytes, macrophages, erythrocytes, and megakaryocytes. This book describes the intricate processes involved in the development of blood cells across a range of organisms from drosophila and fish at one end, and mammals at the other end. It contains individual chapters devoted to describing the epigenetic and transcriptional mechanisms regulating hematopoiesis in the different organisms and orchestrating the differentiation of a wide variety of cell types. Different chapters describe the function of lymphocytes, macrophages and red blood cells and the molecular players, i.e. transcription factors and the epigenetic regulatory machinery driving their differentiation. Most importantly, the book not only describes normal processes, such as the rearrangements of antigen receptor genes, and the regulation of genes by various mechanisms such as DNA methylation, but also outlines what happens when these processes function abnormally to precipitate diseases such as leukemia and immune disorders
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aCélulas sanguíneas _9160868 _0comprobar BNE20030193643 _2embne
650	0	7	_aEpigenética _2embne _9526531
700	1		_aBonifer, Constanze _eeditor literario _985670 _0Local
700	1		_aCockerill, Peter N. _eeditor literario _0Local _985671
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-642-45198-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783642451980
907			_a.b12821640 _b07-11-17 _c01-10-14
998			_am _a_alco _a_vill _b06-11-17 _cm _dz _eu _feng _ggw _h0
945			_aQP91 .T73 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11550855 _z06-04-17
999			_c76546 _d76546 _x1