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008			131218s2014 gw | s |||| 0|eng d
020			_a9783642451799
024	7		_a10.1007/978-3-642-45179-9 _2doi
040			_dES-MaUEC
050		4	_aQH608 _b.B445 2014
100	1		_aBehl, Christian _0Local _985666
245	1	0	_aCell Aging : _b Molecular Mechanisms and Implications for Disease _cby Christian Behl, Christine Ziegler.
260			_aBerlin, Heidelberg _bSpringer International Publishing _c2014
300			_a1 recurso en línea (IX, 108 p.) _b34 ilustraciones, 32 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aSpringerBriefs in Molecular Medicine _x2197-7925
505	0		_aAging and cell aging: an introduction -- Cell cycle: the life cycle of a cell -- Theories and mechanisms of aging -- Selected age-related disorders.
520			_aAging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a variety of human disorders, it is increasingly becoming a central topic in biochemical and medical research. The plethora of theories on aging â€{u0CEF}me of which have been discussed for decades â€{u0872}e neither isolated nor contradictory but instead can be connected in a network of pathways and processes at the cellular and molecular levels. This book summarizes the most prominent and important approaches, focusing on telomeres, DNA damage and oxidative stress as well as on the possible role of nutrition, the interplay between genes and environment (epigenetics) and intracellular protein homeostasis and introduces some genes that have actually extended life spans in animal models. Linking these different determinants of aging with disease, this volume aims to reveal their multiple interdependencies. We see that there is no single “perfectâ€{u0D28}eory of aging and that instead it is possible to define what the authors call the molecular aging matrix of the cell. A better knowledge of its key mechanisms and the mutual connections between its components will lead to a better understanding of age-associated disorders such as Alzheimerâ€{u3824}isease.
650		7	_2embne _aCitología _9139477
650		7	_2embne _9160237 _aMuerte celular
700	1		_aZiegler, Christine _0Local _985667
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-642-45179-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12821615 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQH608 .B445 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i1155082x _z06-04-17
988			_aEBSPRINGER
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0