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003			ES-MaUEC
005			20230207040228.0
007			cr nn 008mamaa
008			140415s2014 gw s 000 0 eng d
020			_a9783642415883
024	7		_a10.1007/978-3-642-41588-3 _2doi
040			_aES-MaUEC
050		4	_aQP356.2 _b.V65 2014 EB
082	0	4	_a615
245	0	0	_aVoltage Gated Sodium Channels _cedited by Peter C. Ruben
264		1	_aBerlin, Heidelberg _bSpringer International Publishing _c2014
300			_a1 recurso en línea (VIII, 295 p.) _b58 ilustraciones, 36 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aHandbook of Experimental Pharmacology _x0171-2004 _v221
505	0		_aOverview: biophysical properties and structure of sodium channels.- The voltage sensor module in sodium channels -- Slow inactivation of Na+ channels -- Regulation/modulation of sensory neuron sodium channels -- Ubiquitylation of voltage-gated sodium channels -- Probing gating mechanisms of sodium channel using pore blockers -- Animal toxins influence voltage-gated sodium channel function -- Voltage-sensor trapping toxins: Iso form-specific ligands for sodium channels -- Pharmacological insights and quirks of bacterial sodium channels -- The role of non-pore-forming Ý subunits in physiology and pathophysiology of voltage-gated sodium channels -- The role of late INa in development of cardiac arrhythmias -- Proton modulation of cardiac INa: A potential arrhythmogenic trigger -- Altered sodium channel gating as molecular basis for pain: Contribution of activation, inactivation and resurgent currents.
520	3		_aA number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied
650	0	7	_aNeurobiología _9139039 _2embne
650	0	7	_aToxicología _0LocalV _2embne _9140328
700	1		_aRuben, Peter C. _0nb2014011650 _eeditor literario _948456
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-642-41588-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783642415883
907			_a.b1282155x _b18-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQP356.2 .V65 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11550764 _z06-04-17
988			_aEBOOK, EBSPRINGERrevisando
998			_am _a_alco _a_vill _b18-10-17 _cm _dz _eu _feng _ggw _h0