000			05081nam a22003855i 4500
001			76536
003			ES-MaUEC
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007			cr nn 008mamaa
008			131218s2014 gw s 000 0 eng d
020			_a9783642415661
024	7		_a10.1007/978-3-642-41566-1 _2doi
040			_aES-MaUEC
050		4	_aQH431 _b.S84 2014 EB
082	0	4	_a571.6
245	0	0	_aSubtelomeres _cedited by Edward J Louis, Marion M Becker
264		1	_aBerlin, Heidelberg _bSpringer International Publishing _c2014
300			_a1 recurso en línea (XIV, 271 p.) _b48 ilustraciones, 19 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aIntroduction to Subtelomeres -- Subnuclear Architecture of Telomeres and Subtelomeres in Budding Yeast -- Subtelomeric Regions Promote Evolutionary Innovation of Gene Families in Yeast -- Subtelomere Organization, Evolution and Dynamics in the Rice Blast Fungus Magnaporthe Oryzae -- Pneumocystis Carinii Subtelomeres -- Subtelomeres of Aspergillus Species -- Trypanosoma Brucei Subtelomeres: Monoallelic Expression and Antigenic Variation -- Human and Primate Subtelomeres -- FSHD: A Subtelomere-Associated Disease -- Characterization of Chromosomal Ends on the Basis of Chromosome-Specific Telomere Variants and Subtelomeric Repeats in Rice -- What is The Specificity of Plane Subtelomeres? -- Subtelomeres in Drosophila and Other Diptera -- Accumulations of Telomere-Repeat-Specific Retrotransposons in Subtelomeres of Bombyx Mori and Tribolium casteneum -- Subtelomere Plasticity in the Bacterium Streptomyces -- Genomics of Subtelomeres: Technical Problems, Solutions and the Future.
520	3		_aNew genes and diversity leading to adaptation and evolution are generated in special areas of genomes. One such area in all eukaryotic genomes and in those prokaryotes with linear chromosomes is the region near the ends of the chromosomes. These telomere-associated sequences, or subtelomeres, have different properties than the rest of the genome and are one of the most exciting frontiers left in genomics. This book provides a broad introduction to the field of subtelomeres with detailed information from various fields and systems, covering yeasts and fungi, pathogens and parasites, plants, insects, humans and primates and bacteria with linear chromosomes. Advances in the field as well as continuing challenges are discussed throughout. The mosaic nature of this collection and the everchanging perspectives reflect the nature of subtelomeres themselves. Unlike the core of most genomes, which are conserved and stable over time, subtelomeres are dynamic and polymorphic, so much so that generally no two individuals look alike in these regions. The dynamic nature of the region and the ability to change the copy number, generate diversity and try novel combinations make it the evolutionary tinker{u2019}s toolbox. In many organisms the genes found in the region are involved in dealing with the environment. In yeasts, different gene families involved in sugar metabolism as well as clumping together are found in subtelomeres and differences in the region may be the reason why some strains are good for baking, others for brewing and why some are pathogenic. In fungal plant and animal pathogens, many of the genes involved in virulence are found here. In humans and primates there are a number of gene families that vary between ends, for example the diverse olfactory receptor genes. Even in bacterial linear chromosomes the region contains genes involved in adapting to their environments. Perhaps the ultimate use of these regions is in parasites where they rapidly adapt and escape from host immune systems through dynamic changes to the proteins exposed to the host{u2019}s defenses. Such dynamic, polymorphic structures are also found in plants and insects though it is not always clear what the function might be; in some cases they take on the role of end maintenance. The dynamic, polymorphic nature of subtelomeres, where many ends share segmental duplications, is an exciting area for study but also presents a difficult challenge from the technical perspective
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aGenética humana _0comprobar BNE19900986777 _2embne _9140562
650		7	_aCromosomas _0comprobar BNE19900979364 _2embne _9139992
700	1		_aLouis, Edward Joh _0n 90676308 _eeditor literario _948451
700	1		_aBecker, Marion M. _0n 2014183465 _eeditor literario _948452
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-642-41566-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783642415661
907			_a.b12821548 _b18-10-17 _c01-10-14
998			_am _a_alco _a_vill _b18-10-17 _cm _dz _eu _feng _ggw _h0
945			_aQH431 .S84 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11550752 _z06-04-17
999			_c76536 _d76536 _x1