000			03048nam a22003615i 4500
999			_c76527 _d76527
001			76527
003			ES-MaUEC
005			20240118111731.0
007			cr nn 008mamaa
008			131022s2014 gw s 000 0|eng d
020			_a9783642405914
024	7		_a10.1007/978-3-642-40591-4 _2doi
040			_aES-MaUEC _bspa _dES-MaUEC
050		4	_aQR201 .B34 _b2014 EB
082	0	4	_a616.9041
245	1	0	_aMolecular Mechanisms in Legionella Pathogenesis _cedited by Hubert Hilbi
264		1	_aBerlin, Heidelberg _bSpringer International Publishing _c2014
300			_a1 recurso en línea (X, 295 p.) _b19 ilustraciones, 2 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aCurrent Topics in Microbiology and Immunology _x0070-217X _v376
505	0		_aFrom amoeba to macrophages: exploring the molecular mechanisms of Legionella infection in both hosts -- The Legionella pneumophila two-component regulatory systems that participate in the regulation of Icm/Dot effectors -- Facets of small RNA-mediated regulation in Legionella pneumophila -- Type II secretion and Legionella virulence -- Effector translocation by the Legionella Icm/Dot type IV secretion system -- Modulation of small GTPases by Legionella -- Host lipidation: A mechanism for spatial regulation of Legionella effectors -- Phosphoinositides and the Legionella pathogen vacuole -- Legionella phospholipases implicated in virulence -- Cytotoxic glucosyltransferases of Legionella pneumophila -- Modulation of the ubiquitination machinery by Legionella -- Host signal transduction and protein kinases implicated in Legionella infection -- Mouse models of Legionnaires d́isease
520	3		_aLegionnaires' disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila. This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to L. pneumophila. Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen L. pneumophila
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aEnfermedades bacterianas _9146593 _2embne
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-642-40591-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783642405914
907			_a.b12821457 _b17-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQR201 .L44 M65 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11550661 _z06-04-17
998			_dz _eu _feng _ggw _h0