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007			cr nn 008mamaa
008			131106s2014 gw s 000 0 eng d
020			_a9783642402524
024	7		_a10.1007/978-3-642-40252-4 _2doi
050		4	_aQR185.8.T2 _bT49 2014 EB
082	0	4	_a616.079
245	0	0	_aThymic Development and Selection of T Lymphocytes _cedited by Thomas Boehm, Yousuke Takahama
264		1	_aBerlin, Heidelberg _bSpringer International Publishing _c2014
300			_a1 recurso en línea (VII, 132 p.) _b11 ilustraciones, 9 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aCurrent Topics in Microbiology and Immunology _x0070-217X _v373
505	0		_aDevelopment and Function of Cortical Thymic Epithelial Cells -- Mechanisms of Thymus Medulla Development And Function -- Self-peptides in TCR Repertoire Selection and Peripheral T Cell Function.-Âåntral Tolerance Induction -- Trafficking to the Thymus -- The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes
520	3		_aThe thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aLinfocitos T _0comprobar BNE19912601605 _2embne _9144344
650		7	_aInmunología _0comprobar BNE19900958507 _2embne _9138330
700	1		_aBoehm, Thomas _eeditor literario _985651 _0Local
700	1		_aTakahama, Yousuke _eeditor literario _985652 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-642-40252-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783642402524
907			_a.b1282138x _b19-10-17 _c01-10-14
998			_am _a_alco _a_vill _b04-10-17 _cm _dz _eu _feng _ggw _h0
945			_aQR185.8 .T2 T49 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11550594 _z06-04-17
999			_c76520 _d76520 _x1