000			04077nam a22003615i 4500
001			76510
003			ES-MaUEC
005			20230207040227.0
007			cr nn 008mamaa
008			130913s2013 gw s 000 0 eng d
020			_a9783642394263
024	7		_a10.1007/978-3-642-39426-3 _2doi
050		4	_aRB147.5 _b.T73 2013 EB
082	0	4	_a572.6
245	1	0	_aTranslation in Mitochondria and Other Organelles _cedited by Anne-Marie Duchn̊e
260			_aBerlin, Heidelberg _bSpringer International Publishing _c2013
300			_a1 recurso en línea (VI, 265 p.) _b44 ilustraciones, 36 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aStructural aspects of mitochondrial ribosome function -- Mechanism and control of protein synthesis in mammalian mitochondria -- Translation in mammalian mitochondria : Order and disorder linked to tRNA and Aminoacyl-tRNA synthetases -- Mitochondrial targeting of RNA and mitochondrial translation in yeast and mammalians -- Mechanisms and control of protein synthesis in yeast mitochondria -- Mitochondrial translation in trypanosomatids -- Translation in mitochondria and apicoplasts in Apicomplexa -- Translation in mitochondria in green alga and higher plants -- Translation in flowering plant chloroplasts -- The chloroplasts as platform for recombinant proteins production
520	3		_aThe present book gives an overview on the similarities and differences of the various translation systems. Moreover, it highlights the mechanisms and control of translation in mitochondria and other organelles such as plastids and apicoplasts in different organisms. Lastly, it offers an outlook on future developments and applications that might be made possible by a better understanding of translation in mitochondria and other organelles.Â{u0369}tochondria and plastids originate from the endosymbiosis of bacteria. Over the course of evolution, most of the bacterial genes have been lost or transferred to the nuclear genome. Present-day mitochondria and plastids retain only a vestige of the genome of the ancestral bacteria, but the few organellar-encoded protein genes remain essential and must be translated. Organellar translation machineries present clear specificities compared to cytosolic translation machineries, but also from one organism to the other. The organellar translation machineries appear to consist of organellar-encoded and nucleus-encoded components. They rely on crosstalk between genomes and are predominantly controlled by specific mechanisms. Organellar ribosomes show clear differences compared to the ancestral bacterial ribosomes or to the cytosolic ones. Moreover, transfer RNAs and aminoacyl-tRNA synthetases are key components of protein-synthesizing systems, and a full set of both types of macromolecules is required in each compartment where translation occurs. Organellar translations are increasingly becoming a subject of investigation. Translation dysfunctions in human mitochondria are responsible for numerous diseases, and organellar translation systems in some parasites offer potential targets for drug development. Lastly, chloroplasts can be used as platforms for the production of recombinant proteins
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aMitocondrias _9147980 _0comprobar BNE19930736376 _2embne
650		7	_aGenética humana _0comprobar BNE19900986777 _2embne _9140562
700	1		_aDuchn̊e, Anne-Marie _0Local _eeditor literario _985632 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-642-39426-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783642394263
907			_a.b12821287 _b13-10-17 _c01-10-14
998			_am _a_alco _a_vill _b13-10-17 _cm _dz _eu _feng _ggw _h0
945			_aRB147.5 .T73 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11550491 _z06-04-17
999			_c76510 _d76510 _x1