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007			cr nn 008mamaa
008			131004s2013 gw | s |||| 0|eng d
020			_a9783642386640
024	7		_a10.1007/978-3-642-38664-0 _2doi
050		4	_aRM388 _b.P43 2013 EB
082	0	4	_a615
245	0	0	_aPharmacotherapy of Pulmonary Hypertension _cedited by Marc Humbert, Oleg V. Evgenov, Johannes-Peter Stasch
264		1	_aBerlin, Heidelberg _bSpringer International Publishing _c2013
300			_a1 recurso en línea (IX, 576 p.) _b66 ilustraciones, 56 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aHandbook of Experimental Pharmacology _x0171-2004 _v218
505	0		_a Preface.- Part I. Pulmonary hypertension: conceptual bases of the disease. Pulmonary hypertension: definition, classification, and epidemiology. Pulmonary hypertension: pathophysiology and signalling pathways. Pulmonary hypertension: pathology. Pulmonary hypertension: biomarkers. Pulmonary hypertension: animal models -- Part II. Pulmonary hypertension: established therapies. General supportive care. Calcium channel blockers. Prostacyclins. Endothelin receptor antagonists. Phosphodiesterase 5 inhibitors -- Part III. Pulmonary hypertension: novel pathways and emerging therapies Soluble guanylate cyclase stimulators. Therapeutics targeting dysregulated redox equilibrium and endothelial dysfunction (NOXs, sGC activators, GSNOR). Rho-kinase inhibitors. Serotonin transporters and serotonin receptors. PDGF inhibitors. Novel anti-proliferative strategies beyond imatinib. Immunosuppressive agents. Vasoactive peptides. Inhibitors of cGMP/cAMP metabolism (MRP4, MRP5, PDE1). Old targets re-visited. Stem cells and cell based therapy -- Part IV. Conclusions and Outlook. Pulmonary hypertension: evidence-based management in the modern era and future directions
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aFarmacología respiratoria _9158438 _0comprobar BNE20011227327 _2embne
700	1		_aHumbert, Marc _eeditor literario _985612 _0Local
700	1		_aEvgenov, Oleg V. _eeditor literario _0Local _985613
700	1		_aStasch, Johannes-Peter _eeditor literario _985614 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-642-38664-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783642386640
907			_a.b12821184 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b19-09-17 _cm _dz _eu _feng _ggw _h0
945			_aRM388 .P43 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11550399 _z06-04-17
999			_c76500 _d76500 _x1