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008			131021s2014 gw | s |||| 0|eng d
020			_a9783642385056
024	7		_a10.1007/978-3-642-38505-6 _2doi
050		4	_aQH324.2 _b.S97 2014 EB
082	0	4	_a570
245	0	0	_aSystems Biology of Metabolic and Signaling Networks : _bEnergy, Mass and Information Transfer _cedited by Miguel A. Aon, Valdur Saks, Uwe Schlattner
260			_aBerlin, Heidelberg _bSpringer International Publishing _c2014
300			_a1 recurso en línea (X, 375 p.) _b90 ilustraciones, 67 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aSpringer Series in Biophysics _x0932-2353 _v16
505	0		_aI Introduction -- From Physiology, Genomes, Systems and Self-Organization to Systems Biology: The Historical Roots of a 21st Century Approach to Complexity -- Systems Biology of Networks: The Riddle and the Challenge -- II Systems Biology of Signaling Networks -- Micrornas and Robustness In Biological Regulatory Networks. A Generic Approach with Applications at Different Levels: Physiologic, Metabolic And Genetic -- Dynamics of Mitochondrial Redox and Energy Networks: Insights from an Experimental-Computational Synergy -- Adenylate Kinase Isoform Network: A Major Hub in Cell Energetics and Metabolic Signaling -- The Control Analysis of Signal Transduction -- III Systems Biology of Cellular Structures and Fluxes -- Moonlighting Function of the Tubulin Cytoskeleton -- Metabolic Dissipative Structures -- Systems Biology Approaches to Cancer Energy Metabolism -- IV Systems Biology of Organ Function -- Network Dynamics in Cardiac Electrophysiology -- Systems Level Regulation of Energy Fluxes via Metabolic Cycles. Role of Creatine and Phosphotransfer Pathways -- V Systems Biology of Microorganisms -- Temporal Partitioning of the Yeast Cellular Network -- Systems Biology and Metabolic Engineering in Bacteria
520	3		_aSystems Biology represents a new paradigm aiming at a whole-organism-level understanding of biological phenomena, emphasizing interconnections and functional interrelationships rather than component parts. The study of network properties, and how they control and regulate behavior from the cellular to organism level, constitutes a main focus of Systems Biology. This book addresses from a novel perspective a major unsolved biological problem: understanding how a cell works and what goes wrong in pathology. The task undertaken by the authors is in equal parts conceptual and methodological, integrative and analytical, experimental and theoretical, qualitative and quantitative, didactic and comprehensive. Essentially, they unravel the spatio-temporal unfolding of interacting mass-energy and information networks at the cellular and organ levels, as well as its modulation through activation or repression by signaling networks to produce a certain phenotype or (patho)physiological response. Starting with the historical roots, in thirteen chapters this work explores the Systems Biology of signaling networks, cellular structures and fluxes, organ and microorganism functions. In doing so, it establishes the basis of a 21st century approach to biological complexity
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aBioinformática _0comprobar BNE20022028248 _2embne _9160489
650		7	_aMetabolismo _0comprobar BNE19900962300 _2embne _9138638
700	1		_aAon, Miguel A. _eeditor literario _985609 _0Local
700	1		_aSaks, Valdur _eeditor literario _985610 _0Local
700	1		_aSchlattner, Uwe _eeditor literario _985611 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-642-38505-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783642385056
907			_a.b12821160 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b26-05-17 _cm _dz _ek _feng _ggw _h0
945			_aQH324.2 .S97 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11550375 _z06-04-17
999			_c76498 _d76498 _x1