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001			76486
003			ES-MaUEC
005			20230207040226.0
007			cr nn 008mamaa
008			130518s2013 gw s 000 0 eng d
020			_a9783642377655
024	7		_a10.1007/978-3-642-37765-5 _2doi
050		4	_aQR184 _b.I58 2013 EB
082	0	4	_a616.079
245	0	0	_aIntrinsic Immunity _cedited by Bryan R. Cullen
264		1	_aBerlin, Heidelberg _bSpringer International Publishing _c2013
300			_a1 recurso en línea (VII, 262 p.) _b23 ilustraciones, 22 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aCurrent Topics in Microbiology and Immunology _x0070-217X _v371
505	0		_aThe APOBEC3 Family of Retroelement Restriction Factors -- Inhibition of Retroviral Replication by Members of the TRIM Protein Family -- The Antiviral Activities of Tetherin -- Restriction of Retroviral Infection of Macrophages -- Rapid Adversarial Co-Evolution of Viruses and Cellular Restriction Factors -- RNA Interference-Mediated Intrinsic Antiviral Immunity in Plants -- RNA Interference-Mediated Intrinsic Antiviral Immunity in Invertebrates -- Roles of MicroRNAs in the Life Cycles of Mammalian Viruses -- Interplay Between DNA Tumor Viruses and the Host DNA Damage Response
520	3		_aRecent research has focused attention on the importance of intrinsic antiviral immunity, i.e. immunity mediated by factors that are constitutively expressed in many cells. In this volume, leading experts provide a comprehensive overview of this relatively new and rapidly evolving field. They cover intrinsic proteinaceous antiviral immune effectors, such as the APOBEC3 and TRIM protein families as well as Tetherin and SAMHD1, which were initially discovered by researchers studying HIV-1. Furthermore, the role of RNA interference in antiviral defense in plants and invertebrates, as well as the interplay between microRNAs and viruses in mammalian cells, are analysed. One chapter discusses how intrinsic immunity and viral countermeasures to intrinsic immune effectors drive both pathogen and host evolution, and finally the emerging evidence that DNA damage response proteins restrict infection by DNA viruses is highlighted
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aInmunología _0comprobar BNE19900958507 _2embne _9138330
650	0	4	_9413643 _aVirología médica
700	1		_aCullen, Bryan R. _eeditor literario _985582 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-642-37765-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783642377655
907			_a.b12821044 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b19-09-17 _cm _dz _eu _feng _ggw _h0
945			_aQR184 .I58 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11550259 _z06-04-17
999			_c76486 _d76486 _x1