000			04174nam a22003975i 4500
001			76477
003			ES-MaUEC
005			20230207040226.0
007			cr nn 008mamaa
008			130514s2013 gw s 000 0 eng d
020			_a9783642368271
024	7		_a10.1007/978-3-642-36827-1 _2doi
050		4	_aRA566 _b.E88 2013 EB
082	0	4	_a611.01816
082	0	4	_a599.935
245	0	0	_aEnvironmental Epigenomics in Health and Disease : _bEpigenetics and Complex Diseases _cedited by Randy L. Jirtle, Frederick L. Tyson
260			_aBerlin, Heidelberg _bSpringer International Publishing _c2013
300			_a1 recurso en línea (XIV, 339 p.) _b26 ilustraciones, 16 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aEpigenetics and Human Health _x2191-2262
505	0		_aPreface -- Epigenetic programming of the brain -- Epigenetics and maternal brain evolution -- Social environment and DNA methylation: A mechanism for linking nurture and nature -- Sex differences in epigenetic programming of brain differentiation: Implications for mental health and disease -- Epigenetics and neurological disorders -- Phenotypic plasticity, pleiotropy, and the growth-first theory of imprinting -- The imprinted brain: How genes set the balance between autism and psychosis -- Epigenetics at the interface of genetics and environmental factors in autism -- Epigenomic and non-coding RNA regulation in addictive processes -- Epigenetic therapies in neurological diseases -- Epigenetics, nutrition, diabetes, and obesity -- Nutrition, histone epigenetic marks, and disease -- Chromatin switching and gene dynamics associated with type 2 diabetes -- Developmental epigenetic programming in diabetes and obesity -- Epigenetics and cancer -- Developmental reprogramming by environmental estrogens: How early life exposures affect cancer risk in adulthood.- Human cancer epigenetics -- Epigenetics and the law -- Legal and ethical implications of epigenetics -- Subject index
520	3		_aThe capacity of the epigenome to interpret both internal and external stimuli and alter expression programs is a critical component in normal development, aging, and disease pathogenesis. In the past decade, we have witnessed an explosion of unprecedented research on and support for epigenetics, epigenomics, and their interface with human health and disease. In this volume, Environmental Epigenomics in Health and Disease - Epigenetics and Complex Diseases, a number of leading investigators in the field of epigenetics discuss patterns of epigenomic modifications in normal cells, and how environmentally-induced changes in them are associated with disease pathogenesis. The authors comprehensively review the epigenetic adaptations that occur in human embryonic stem cells, as well as in differentiating cells and organs such as the brain when exposed to environmental factors, and discuss the legal and ethical implications of such alterations. The overall purpose of this volume and its companion, Environmental Epigenomics in Health and Disease - Epigenetics and Disease Origins, is to give readers an overview of how environmental exposures during early development can influence disease formation by disrupting epigenetic programming
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aToxicología ambiental _0comprobar BNE20013502493 _2embne _9159275
650		7	_9138405 _aEpidemiología _0comprobar BNE19900959430 _2embne
700	1		_aJirtle, Randy L. _eeditor literario _985465 _0Local
700	1		_aTyson, Frederick L. _eeditor literario _985466 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-642-36827-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783642368271
907			_a.b12820957 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b07-09-17 _cm _dz _eu _feng _ggw _h0
945			_aRA566 .E88 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11550168 _z06-04-17
999			_c76477 _d76477 _x1