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007			cr nn 008mamaa
008			130514s2013 gw | s |||| 0|eng d
020			_a9783642366482
024	7		_a10.1007/978-3-642-36648-2 _2doi
050		4	_aQP355.2 _b.P76 2013 EB
082	0	4	_a612.8
245	0	0	_aProgrammed Cells from Basic Neuroscience to Therapy _cedited by Fred H. Gage, Yves Christen.
260			_aBerlin, Heidelberg _bSpringer International Publishing _c2013
300			_a1 recurso en línea (XII, 130 p.) _b14 ilustraciones, 13 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aResearch and Perspectives in Neurosciences _x0945-6082 _v20
505	0		_aNuclear reprogramming by eggs and oocytes and eventual prospects of cell replacement therapy.-iPS technology and disease research: issues to be resolved -- ES and iPS cells as tools for modeling human aging .-Characterizing neural circuitry with programmed human neurons.-Direct conversion of fibroblasts to neuronal cells -- Human pluripotent stem cells as tools for modelling neurodegeneration.-From Rett syndrome to classical autism: modeling autism spectrum disorders using human neurons.-Testing evolutionary principles in a dish using embryonic stem cells: the example of the Huntington's Disease gene.-Using stem cells to discover therapeutic targets in ALS and SMA .-Using stem cells to understand and treat Alzheimer's disease.-Using pluripotent stem cells to decipher mechanisms and identify treatments for diseases that affect the brain.-Modeling neural development and disease in human pluripotent stem cells -- Subject index
520			_aThe recent advances in Programming Somatic Cell (PSC) including induced Pluripotent Stem Cells (iPS) and Induced Neuronal phenotypes (iN), has changed the experimental landscape and opened new possibilities. The advances in PSC have provided an important tool for the study of human neuronal function as well as neurodegenerative and neurodevelopmental diseases in live human neurons in a controlled environment. For example, reprogramming cells from patients with neurological diseases allows the study of molecular pathways particular to specific subtypes of neurons such as dopaminergic neurons in Parkinsons Disease, Motor neurons for Amyolateral Sclerosis or myelin for Multiple Sclerosis. In addition, because PSC technology allows for the study of human neurons during development, disease-specific pathways can be investigated prior to and during disease onset. Detecting disease-specific molecular signatures in live human brain cells, opens possibilities for early intervention therapies and new diagnostic tools. Importantly, it is now feasible to obtain gene expression profiles from neurons that capture the genetic uniqueness of each patient. Importantly, once the neurological neural phenotype is detected in vitro, the so-called disease-in-a-dish approach allows for the screening of drugs that can ameliorate the disease-specific phenotype. New therapeutic drugs could either act on generalized pathways in all patients or be patient-specific and used in a personalized medicine approach. However, there are a number of pressing issues that need to be addressed and resolved before PSC technology can be extensively used for clinically relevant modeling of neurological diseases
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aNeurofisiología _0comprobar BNE19912762456 _2embne _9144482
650		7	_aNeuropsicología _0comprobar BNE19900992853 _2embne _9141010
700	1		_aGage, Fred H. _eeditor literario _985573 _0Local
700	1		_aChristen, Yves _eeditor literario _919362 _0comprobar BNE19912857697
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-642-36648-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783642366482
907			_a.b12820933 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b15-07-17 _cm _dz _ei _feng _ggw _h0
945			_aQP355.2 P76 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11550144 _z06-04-17
999			_c76475 _d76475 _x1