000			02844nam a2200349 c 4500
001			76434
003			ES-MaUEC
005			20230207040224.0
008			121214s2013 gw | s |||| 0|eng d
020			_a9783642335709
040			_aES-MaUEC
050		4	_aQP632.B66 _bB68 2013 EB
082	0	4	_a615
245	0	0	_aBotulinum Neurotoxins _cedited by Andreas Rummel, Thomas Binz
260			_aBerlin, Heidelberg _bSpringer International Publishing _c2013
300			_a1 recurso en línea (X, 321 p.) _b48 ilustraciones
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aCurrent Topics in Microbiology and Immunology _x0070-217X _v364
520			_aBotulinum neurotoxins are the most toxic natural substances and represent a major threat to the population when intentionally released in bioterrorist attacks. On the other hand, during the past two decades botulinum neurotoxins have become established as indispensable drugs for the treatment of a variety of severe neurological disorders. The need for efficient countermeasures as well as the expansion into additional fields of therapeutic application, call for comprehensive information on the botulinum neurotoxin molecules and their mode of action. Our knowledge of this subject has made great strides in recent years, setting the stage for the development of new botulinum neurotoxin-based molecules and novel applications. This book reviews the current status of basic botulinum neurotoxin research. The first part describes the genetic variability of the toxin-producing bacteria, and sheds light on each step from toxin ingestion to the abrogation of synaptic signaling including the intestinal passage and absorption, nerve cell binding and entry, and intracellular substrate cleavage. The remaining chapters detail progress made in detection methods for botulinum neurotoxins, the development of botulinum neurotoxin inhibitors, and strategies to refine the neurotoxins for further medicinal applications by means of recombinant technologies.
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aToxina botulínica _0comprobar BNE20012840947 _2embne _9159095
700	1		_aRummel, Andreas _eeditor literario _985511 _0Local
700	1		_aBinz, Thomas _eeditor literario _985512 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-642-33570-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783642335709
907			_a.b12820520 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b28-04-17 _cm _dz _ef _feng _ggw _h0
945			_aQP632 .B66 B68 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11549737 _z06-04-17
999			_c76434 _d76434 _x1