000			03301nam a22003855i 4500
001			76409
003			ES-MaUEC
005			20230207040223.0
007			cr nn 008mamaa
008			121212s2013 gw | s |||| 0|eng d
020			_a9783642279287
024	7		_a10.1007/978-3-642-27928-7 _2doi
050		4	_aRC365 _b.P76 2013 EB
082	0	4	_a612.8
245	0	0	_aProtein Quality Control in Neurodegenerative Diseases _cedited by Richard I. Morimoto, Yves Christen
260			_aBerlin, Heidelberg _bSpringer International Publishing _c2013
300			_a1 recurso en línea (XII, 135 p.) _b20 ilustraciones, 17 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aResearch and Perspectives in Alzheimer's Disease _x0945-6066
505	0		_aThe Regulation and Function of the Heat Shock Response by Eric Guisbert and Richard I. Morimoto -- The Endoplasmic Reticulum Unfolded Protein Response and Neurodegeneration by David Ron -- Proteostasis and the aging pathways by Ian Nicastro and Andrew Dillin -- The Membrane Sources of Macroautophagy by Daniel J. Klionsky, Melinda A. Lynch-Day, Jiefei Geng, and Wei-Lien Yen -- Selective Autophagy in Cellular Quality Control by Susmita Kaushik and Ana Maria Cuervo -- Quality Control of Proteins and Organelles by Autophagy by Noboru Mizushima -- The Role of the Co-Chaperone BAG3 in Selective Macroautophagy: Implications for Aging and Disease by Christian Behl -- Predicting Fates in Models of Neurodegenerative Disease: Longitudinal Measures of Protein Homeostasis in Live Neurons by Steven Finkbeiner -- Therapeutic Potential of Longevity Modulators as Neuroprotective Targets in Neurodegenerative Disease by Rafael Vazquez-Manrique, Cendrine Tourette and Christian Neri -- Subject code.
520	3		_aThe health of the proteome depends upon protein quality control to regulate the proper synthesis, folding., translocation, and clearance of proteins. The cell is challenged constantyl by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aSistema nervioso _xDegeneración _9313064 _0comprobar BNE20012072191 _2embne
650		7	_aNeurociencias _0comprobar BNE20012490612 _2embne _9158907
700	1		_aMorimoto, Richard I. _eeditor literario _985469 _0Local
700	1		_aChristen, Yves _eeditor literario _919362 _0comprobar BNE19912857697
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-642-27928-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783642279287
907			_a.b12820271 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b19-06-17 _cm _dz _ek _feng _ggw _h0
945			_aRC365 .P76 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i1154949x _z06-04-17
999			_c76409 _d76409 _x1