000			03355nam a22003855i 4500
001			76367
003			ES-MaUEC
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007			cr nn 008mamaa
008			100301s2006 gw | s |||| 0|eng d
020			_a9783540329527
024	7		_a10.1007/3-540-32952-8 _2doi
040			_aES-MaUEC
050		4	_aQR46 _b.M93 2006 EB
082	0	4	_a616.9041
245	0	4	_aThe Myc/Max/Mad Transcription Factor Network _cedited by R. N. Eisenman
260			_aBerlin, Heidelberg _bSpringer International Publishing _c2006
300			_a1 recurso en línea (VII, 282 p.)
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aCurrent Topics in Microbiology and Immunology _x0070-217X _v302
505	0		_aMaking Myc -- Transcriptional Activation by the Myc Oncoprotein -- Mechanisms of Transcriptional Repression by Myc -- The Mad Side of the Max Network: Antagonizing the Function of Myc and More -- Structural Aspects of Interactions Within the Myc/Max/Mad Network -- Myc Target Transcriptomes -- c-Myc, Genome Instability, and Tumorigenesis: The Devil Is in the Details -- Lessons Learned from Myc/Max/Mad Knockout Mice -- Myc/Max/Mad in Invertebrates: The Evolution of the Max Network -- The Mlx Network: Evidence for a Parallel Max-Like Transcriptional Network That Regulates Energy Metabolism.
520			_aIntense study of the enigmatic myc proto-oncogene over the last 20 years has broadened our view of its functions and led to insights into transcriptional regulation as well as cancer etiology, cell proliferation, apoptosis, and organismal development. How can one gene be involved in so many aspects of cellular behavior? Of particular interest is the fact that the Myc protein functions as part of a network (comprising Myc, Max, and Mad proteins) whose specific interactions direct transcriptional activation or repression of a large number of target genes. The chapters in this volume examine both molecular and biological aspects of the Myc/Max/Mad network. Included are contributions concerning the regulation of its expression, the mechanisms underlying its diverse transcriptional activities, the structural bases for its critical interactions, and the nature of its target genes. Other chapters explore the evolution of the network, its role in development and genomic instability, and the evidence for a parallel transcriptional network. Overall, this volume provides a broad and current overview of research on a crucial group of transcription factors.
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_9405049 _aMicrobiología médica _0comprobar BNE19900963008 _2embne
650		7	_aGenética humana _0comprobar BNE19900986777 _2embne _9140562
700	1		_aEisenman, R. N. _eeditor literario _913450 _0comprobar BNE20011029406
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/3-540-32952-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783540329527
907			_a.b12819852 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b22-07-17 _cm _dz _ei _feng _ggw _h4
945			_aQR46 .M93 2006 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11549075 _z06-04-17
999			_c76367 _d76367 _x1