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007			cr nn 008mamaa
008			100301s2006 gw | s |||| 0|eng d
020			_a9783540329480
024	7		_a10.1007/978-3-540-32948-0 _2doi
050		4	_aQL801 _b.E67 vol. 185 EB
082	0	4	_a610
700	1		_aNeuhuber, W. L. _eeditor literario. _985397 _0Local _1http://viaf.org/viaf/72280549
245	0	0	_aInnervation of the Mammalian Esophagus _cedited by W.L. Neuhuber.
264		1	_aBerlin, Heidelberg _bSpringer International Publishing _c2006.
300			_a1 recurso en línea (X, 76 páginas) _b14 ilustraciones
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aAdvances in Anatomy, Embryology and Cell Biology _x0301-5556 _v185
505	0		_aIntroduction -- Muscle layers of the esophagus -- Materials and Methods. Anterograde WGA-HRP tracing from nodose ganglion. Anterograde DiI tracing from thoracic dorsal root ganglia -- Extrinsic innervation. Vagal innervation -- Spinal innervation. Innervation of esophageal sphincters. Swallowing central pattern generator. Cortical representation of the esophagus in human -- Intrinsic innervation. General organization. Enteric coinnervation -- Functional considerations. General remarks. Cooperation between extrinsic and intrinsic systems -- Concluding remarks -- Summary -- References -- Subject Index.
520			_aUnderstanding the innervation of the esophagus is a prerequisite for successful treatment of a variety of disorders, e.g., dysphagia, achalasia, gastroesophageal reflux disease (GERD) and non-cardiac chest pain. Although, at first glance, functions of the esophagus are relatively simple, their neuronal control is considerably complex. Vagal motor neurons of the nucleus ambiguus and preganglionic neurons of the dorsal motor nucleus innervate striated and smooth muscle, respectively. Myenteric neurons represent the interface between the dorsal motor nucleus and smooth muscle but are also involved in striated muscle innervation. Intraganglionic laminar endings (IGLEs) represent mechanosensory vagal afferent terminals. They also establish intricate connections with enteric neurons. Afferent information is implemented by the swallowing central pattern generator in the brainstem, which generates and coordinates deglutitive activity in both striated and smooth esophageal muscle and orchestrates esophageal sphincters as well as gastric adaptive relaxation. Disturbed excitation/inhibition balance in the lower esophageal sphincter results in motility disorders, e.g., achalasia and gastroesophageal reflux disease. Loss of mechanosensory afferents disrupts adaptation of deglutitive motor programs to bolus variables, eventually leading to megaesophagus. Both spinal and vagal afferents appear to contribute to painful sensations, e.g., non-cardiac chest pain. Extrinsic and intrinsic neurons may be involved in intramural reflexes using acetylcholine, nitric oxide, substance P, CGRP and glutamate as main transmitters. In addition, other molecules, e.g., ATP, GABA and probably also inflammatory cytokines may modulate these neuronal functions.
650		7	_aAnatomía _2embne _9138486
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-540-32948-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12819840 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aR-RZ EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11549063 _z06-04-17
988			_aEBOOK, EBSPRINGERrevisando, GOBI_sep2018
988			_aEbook_one2one
998			_aSI _a_alco _a_vill _b10/2018 _cm _dz _ek _feng _ggw _h0
999			_c76366 _d76366 _x1