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007			cr nn 008mamaa
008			100301s2006 gw | s |||| 0|eng d
020			_a9783540306573
024	7		_a10.1007/3-540-30657-9 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQR1 _b2006 EB
082	0	4	_a616.079
100	1		_aHonjo, Tasuku _eeditor literario _0Local _985342
245	1	0	_aGut-Associated Lymphoid Tissues _cedited by Tasuku Honjo, Fritz Melchers.
260			_aBerlin, Heidelberg _bSpringer International Publishing _c2006
300			_a1 recurso en línea (XI, 210 p.) :
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aCurrent Topics in Microbiology and Immunology _x0070-217X _v308
505	0		_aRole of the Innate Immune System and Host-Commensal Mutualism -- Molecular Networks Orchestrating GALT Development -- Lymphoid Tissue Inducer Cells in Intestinal Immunity -- Specificity and Plasticity of Memory LymphocyteMigration -- IgA Adaptation to the Presence of Commensal Bacteria in the Intestine -- Intestinal IgA Synthesis: A Primitive Form of Adaptive Immunity That Regulates Microbial Communities in the Gut -- B Cell Recruitment and Selection in Mouse GALT Germinal Centers -- Structural Insights into Antibody-Mediated Mucosal Immunity.
520			_aThe intestine is the front line of the confrontation between pathogens and the immune system. However, it is also important to emphasize that we have a symbiotic relationship with innumerable bacteria in the intestine. In the gastrointestinal tract of mammals the lower intestine harbors around 1,000 12 species of anaerobic and aerobic bacteria, in densities up to 10 /mlinthe distal small intestine, the cecum, and the colon. A single layer of epithelial cells of the intestine protects the internal organs of the mammalian host from these bacteria. Below these epithelial cells the gut-associated lymphoid tissues (GALT), organized in Peyerâ€{u3830}atches, cryptopatches, and isolated l- phoid follicles, as well as isolated, dispersed single cells in the epithelial layer (intraepithelial lymphocytes) and lamina propria, are composed of T l- phocytes, B lymphocytes, Ig-secreting plasma cells, and antigen-presenting cells such as dendritic cells. The importance of the gut barrier is striking, if we consider that in humans the epithelial surface, behind which the immune system faces and senses the endogenous bacteria, is estimated to be as large as a basketball court. Perhaps not surprising then, the gut contains appr- imately half of all lymphocytes of our immune system. Colonization of the intestine with the ?ora of commensal bacteria induces the development of the GALT, which in turn responds by the development of IgA-secreting plasma cells. Dimeric and multimeric IgAs can traverse the epithelial layer and are released in the gut lumen, where they bind bacteria.
650		7	_aIntestinos _2embne _9680170 _xMicrobiología
650		7	_aInmunología _2embne _9138330
700	1		_aMelchers, Fritz _eeditor literario _985343 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/3-540-30657-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12819505 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQR180-189.5 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11548721 _z06-04-17
988			_aEBOOK, EBSPRINGERrevisando
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0