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008			100301s2006 gw | s |||| 0|eng d
020			_a9783540297178
024	7		_a10.1007/3-540-29717-0 _2doi
040			_aES-MaUEC
050		4	_aQP552.M64 _bM65 2006 EB
082	0	4	_a615
245	1	0	_aMolecular Chaperones in Health and Disease _cedited by K. Starke, Matthias Gaestel
260			_aBerlin, Heidelberg _bSpringer International Publishing _c2006
300			_a1 recurso en línea (IX, 442 p.) _b36 ilustraciones
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aHandbook of Experimental Pharmacology _x0171-2004 _v172
505	0		_aChaperones in Preventing Protein Denaturation in Living Cells and Protecting Against Cellular Stress -- Feedback Regulation of the Heat Shock Response -- Protein Folding in the Endoplasmic Reticulum and the Unfolded Protein Response -- Molecular Chaperones in Signal Transduction -- Chaperoning of Glucocorticoid Receptors -- Heat Shock Response: Lessons from Mouse Knockouts -- HSFs in Development -- Heat Shock Proteins: Endogenous Modulators of Apoptotic Cell Death -- Protein Aggregation as a Cause for Disease -- The Role of Chaperones in Parkinson's disease and Prion Diseases -- Chaperoning Oncogenes: Hsp90 as a Target of Geldanamycin -- Heat Shock Proteins in Immunity -- Molecular Chaperones and Cancer Immunotherapy -- Hsp90 Inhibitors in the Clinic -- Pharmacological Targeting of Catalyzed Protein Folding: The Example of Peptide Bond cis/trans Isomerases -- Chemical Chaperones: Mechanisms of Action and Potential Use -- Pharmacological Modulation of the Heat Shock Response.
520			_aMolecular chaperones are involved in a wide variety of essential cellular processes in living cells. A subset of molecular chaperones have been initially described as heat shock proteins protecting cells from stress damage by keeping cellular proteins in a folding competent state and preventing them from irreversible aggregation. Later it became obvious that molecular chaperones are also expressed constitutively in the cell and are involved in complex processes such as protein synthesis, intracellular protein transport, post-translational modification and secretion of proteins as well as receptor signalling. Hence, it is not surprising that molecular chaperones are implicated in the pathogenesis of many relevant diseases and could be regarded as potential pharmacological targets. Starting with the analysis of the mode of action of chaperones at the molecular, cellular and organismic level, this book will then describe specific aspects where modulation of chaperone action could be of pharmacological and therapeutic interest
650		7	_aProteínas _0comprobar BNE19900977845 _2embne _9139861
650		7	_aBiología molecular _2embne _9139103
700	1		_aStarke, K. _eeditor literario _985320 _0Local
700	1		_aGaestel, Matthias _eeditor literario _985321 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/3-540-29717-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783540297178
907			_a.b12819384 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQP552 .M64 M65 2006 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11548605 _z06-04-17
988			_aEBOOK, EBSPRINGERrevisando
998			_am _a_alco _a_vill _b15-07-17 _cm _dz _eu _feng _ggw _h0