000			04065nam a22003855i 4500
001			76296
003			ES-MaUEC
005			20230207040218.0
007			cr nn 008mamaa
008			100301s2006 gw s 000 0 eng d
020			_a9783540272786
024	7		_a10.1007/b138868 _2doi
040			_aES-MaUEC
050		4	_aQP551 _b.N65 2006 EB
082	0	4	_a572
100	1		_aNölting, Bengt _985271 _0Local
245	1	0	_aProtein Folding Kinetics : _bBiophysical Methods _cby Bengt Nölting
250			_aSecond Edition
260			_aBerlin, Heidelberg _bSpringer International Publishing _c2006
300			_a1 recurso en línea (XIV, 222 p.) _b170 ilustraciones, 12 en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aStructures of proteins -- Physical interactions that determine the properties of proteins -- Calculation of the kinetic rate constants -- High kinetic resolution of protein folding events -- Kinetic methods for slow reactions -- Resolution of protein structures in solution -- High structural resolution of transient protein conformations -- Experimental problems of the kinetic and structural resolution of reactions that involve proteins -- The folding pathway of a protein (barstar) at the resolution of individual residues from microseconds to seconds -- Highly resolved folding pathways and mechanisms of six proteins -- Structural determinants of the rate of protein folding -- Evolutionary computer programming of protein structure and folding -- Conclusions
520			_aThe book gives a deep insight into the principles and concepts of the kinetic and structural resolution of fast chemical and biophysical reactions of proteins with emphasis on protein-folding reactions. The study of fast protein-folding reactions and the understanding of the folding paradox have significantly advanced due to the recent development of new biophysical methods which allow not only kinetic resolution in the sub-millisecond time scale but also structural resolution with unprecedented precision. Pathways and structures of early and late folding events and the transition state structures of fast- and ultrafast-folding proteins can now be studied in far more detail. Important techniques include biophysical, chemical, molecular biological and mathematical methods, in particular protein engineering, Phi-value analysis, time-resolved circular dichroism, optical triggers and pulsed infrared LASER methods, pressure and temperature jump, ultrafast mixing, stopped flow and quenched flow, dielectric relaxation and electric-field-jump, acoustic relaxation, fluorescence- and isotope-labeling, H/D exchange methods, NMR line broadening and stopped-flow NMR, transition state theory, solutions of rate equations, and evolutionary computer programming. Protein Folding Kinetics - Biophysical Methods is written for students and researchers in biochemistry, biophysics, and related fields. Special features in the second edition: includes detailed information and 12 color figures on the high resolution of folding transition states.Discusses structural determinants of the rate of protein folding on a timescale from microseconds to seconds. â€вovides information on self-evolving computer programs for protein-folding simulations and protein-structure predictions.
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aProteínas _0comprobar BNE19900977845 _2embne _9139861
650		7	_aCinética química _0comprobar BNE19973712429 _2embne _9153087
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/b138868 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783540272786
907			_a.b12819141 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b18-07-17 _cm _dz _eu _feng _ggw _h0
945			_aQP551 .N65 2006 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11548368 _z06-04-17
999			_c76296 _d76296 _x1