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007			cr nn 008mamaa
008			100301s2006 gw s 000 0 eng d
020			_a9783540272625
024	7		_a10.1007/b138836 _2doi
040			_bspa _cES-MaUEC _dES-MaUEC
050		4	_aQP623 _b.R63 2006 EB
245	0	0	_aRNA Towards Medicine _cedited by Volker Erdmann, Jan Barciszewski, Jürgen Brosius
246	3		_aWith contributions by numerous experts
260			_aBerlin, Heidelberg _bSpringer International Publishing _c2006
300			_a1 recurso en línea (XI, 464 p.) :
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aHandbook of Experimental Pharmacology _x0171-2004 _v173
505	0		_aWhy RNA and DNA Have Different Structures -- Regulatory RNAs as Mediators of Virulence Gene Expression in Bacteria -- Regulatory RNAs in Mammals -- Aminoglycoside Interactions with RNAs and Nucleases -- High-Throughput RNA Interference in Functional Genomics -- Antiviral Applications of RNAi -- RNA Interference: Its Use as Antiviral Therapy -- Gene Silencing of Virus Replication by RNA Interference -- Progress in the Development of Nucleic Acid Therapeutics -- Screening and Determination of Gene Function Using Randomized Ribozyme and siRNA Libraries -- Ribozymes and siRNAs: From Structure to Preclinical Applications -- Strategies to Identify Potential Therapeutic Target Sites in RNA -- Oligonucleotide-Based Antiviral Strategies -- Gene-Expressed RNA as a Therapeutic: Issues to Consider, Using Ribozymes and Small Hairpin RNA as Specific Examples -- RNA Aptamers: From Basic Science Towards Therapy -- RNA Aptamers Directed Against Oligosaccharides -- Aptamer-Based Biosensors: Biomedical Applications -- Application of Aptamers in Therapeutics and for Small-Molecule Detection -- RNA Aptamers as Potential Pharmaceuticals Against Infections with African Trypanosomes -- RNA Targeting Using Peptide Nucleic Acid -- Locked Nucleic Acid: High-Affinity Targeting of Complementary RNA for RNomics -- Engineering RNA-Based Circuits -- Selection of RNase-Resistant RNAs.
520	3		_aDevelopments over the past few years have revealed the remarkable versatility of RNA in any compartment of the cell, tasks that had been thought to be exclusively in the realm of proteins and even beyond. The chapters in this book written by leading investigators in the field provide insight into various promising avenues where RNA and nucleic acid derivatives including antisense RNAs, such as siRNA, miRNAs, amplification/selection (SELEX) generated aptamers as well as ribozymes are at the threshold of impacting medicine
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aARN _0comprobar BNE19913480892 _2embne _9144940
650		7	_aToxicología _0comprobar BNE19900983730 _2embne _9140328
700			_aErdmann, Volker _eeditor literario _0Local _985268
700	1		_aBarciszewski, Jan _eeditor literario _985269 _0Local
700	1		_aBrosius, Jürgen _eeditor literario _985270 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/b138836 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783540272625
907			_a.b1281913x _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQP623 .R63 2006 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11548356 _z06-04-17
998			_dz _eu _feng _ggw _h0