000			02727nam a22003615i 4500
001			76288
003			ES-MaUEC
005			20230202102006.0
007			cr nn 008mamaa
008			140805s2014 gw | s |||| 0|eng d
020			_a9783319089218
024	7		_a10.1007/978-3-319-08921-8 _2doi
050		4	_aQP551 _b.U947 2014 EB
082	0	4	_a572.633
100	1		_aUversky, Vladimir N. _984098 _0Local
245	1	0	_aIntrinsically Disordered Proteins _cby Vladimir N. Uversky.
260			_aCham, Switzerland _bSpringer International Publishing _c2014
300			_a1 recurso en línea (XV, 61 p.) _b13 ilustraciones, 10 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aSpringerBriefs in Molecular Science _x2191-5407
505	0		_aIntroducing the phenomenon of protein intrinsic disorder -- Peculiar amino acid sequences of soluble IDPs -- Natural abundance of IDPs/IDPRs -- Wavy evolution of intrinsic disorder: Reinventing the wheel -- Structural heterogeneity of IDPs: When almost everything is possible -- Typical functions of IDPs and IDPRs -- Binding promiscuity and multitude of the disorder-based binding modes -- IDPs/IDPRs in human diseases -- IDPs as potential drug targets -- Concluding remarks: Intrinsic disorder as a universal tool for solving protein mysteries and riddles
520	3		_aIn this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on to describe the peculiar amino acid sequences of IDPs, their structural heterogeneity, typical functions and disorder-based binding modes. In the final sections, Uversky discusses IDPs in human diseases and as potential drug targets. This volume provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aProteínas _0comprobar BNE19900977845 _2embne _9139861
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-08921-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319089218
907			_a.b12819062 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b05-07-17 _cm _dz _ek _feng _ggw _h0
945			_aQP551 .U947 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11548289 _z06-04-17
999			_c76288 _d76288 _x1