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008			140918s2014 gw s 000 0 eng d
020			_a9783319088945
024	7		_a10.1007/978-3-319-08894-5 _2doi
050		4	_aQP562.G5 _bG58 2014 EB
082	0	4	_a612.8
245	0	0	_aGlutamate and ATP at the Interface of Metabolism and Signaling in the Brain _cedited by Vladimir Parpura, Arne Schousboe, Alexei Verkhratsky.
260			_aCham, Switzerland _bSpringer International Publishing _c2014
300			_a1 recurso en línea (XVII, 261 p.) _b61 ilustraciones, 39 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aAdvances in Neurobiology _x2190-5215 _v11
505	0		_a1. Glutamate and ATP: The Crossroads of Signaling and Metabolism in the Brain -- 2. Glutamate Metabolism in the Brain Focusing on Astrocytes -- 3. Glycogenolysis and Purinergic Signaling -- 4. Purinergic and Glutamatergic Receptors on Astroglia -- 5. Regulated Exocytosis in Astrocytes Is as Slow as the Metabolic Availability of Gliotransmitters: Focus on Glutamate and ATP -- 6. Adenosine and Glutamate in Neuroglial Interaction: Implications for Circadian Disorders and Alcoholism -- 7. Purinergic Receptor Stimulation Decreases Ischemic Brain Damage By Energizing Astrocyte Mitochondria -- 8. Excitotoxicity and Mitochondrial Dysfunction Underlie Age-dependent Ischemic White Matter Injury -- 9. Role of Astrocytes in Delayed Neuronal Death: GLT-1 and its Novel Regulation by MicroRNAs -- 10. Ca2+ Signaling in Astrocytes and its Role in Ischemic Stroke -- 11. Pathological Potential of Astroglial Purinergic Receptors.
520	3		_aATP was naturally selected very early on as the main source of biological energy, and thus became an indispensable feature of life on the Earth. This was a critical evolutionary choice because it shaped enzymatic systems to utilize ATP in energy-dependent reactions and necessitated an appearance of the universal intracellular signaling system based on calcium ions; keeping cytosolic Ca2+ extremely low became vitally important, since otherwise insoluble Ca2+-phosphates would preclude the cell energetics. Thus, all living cells on the Earth, beginning from the most primitive ones, had high cytosolic concentrations of ATP and there is little surprise that ATP was soon utilized by nature for another fundamental function of sending information from one living cell to another. In summary, ATP acts as the main energy source and is pivotal for numerous signaling cascades both inside (by fueling various transport systems and donating phosphate groups) and between the cells (by chemical transmission). Similarly, glutamate acts as an important molecule for both intercellular signaling through glutamatergic transmission and cell energetics by contributing to ATP production. In this collection of chapters, written by the leading experts in the fields of cell metabolism and energetics, intracellular signaling and neurotransmission, we covered various aspects of the interfacing between these two fundamental molecules. This book will be particularly useful for researchers, students, physicians and psychotherapists working in the field of neurobiology, neurology and psychiatry.
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aÁcido glutámico _9155047 _0comprobar BNE19985024102 _2embne
650		7	_aNeurociencias _0comprobar BNE20012490612 _2embne _9158907
700	1		_aParpura, Vladimir _eeditor literario _985037 _0Local
700	1		_aSchousboe, Arne _eeditor literario _985261 _0Local
700	1		_aVerkhratsky, Alexei _eeditor literario _985038 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-08894-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319088945
907			_a.b12819050 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b11-07-17 _cm _dz _eu _feng _ggw _h0
945			_aQP562 .G5 G58 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11548277 _z06-04-17
999			_c76287 _d76287 _x1