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008			140411s2014 gw | s |||| 0|eng d
020			_a9783319058795
024	7		_a10.1007/978-3-319-05879-5 _2doi
040			_bspa _dES-MaUEC
050		4	_aQR1 _b.O437 2014
082	0	4	_a616.079
100	1		_aOldstone, Michael B. A. _eeditor. _985210 _0Local
245	1	0	_aSphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases _cedited by Michael B. A. Oldstone, Hugh Rosen.
260			_aCham, Switzerland _bSpringer _c2014
300			_a1 recurso en línea (VII, 184 p.) _b27 ilustraciones, 22 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aCurrent Topics in Microbiology and Immunology _x0070-217X _v378
505	0		_aThe organization of the sphingosine-1-phosphate signaling system -- Structural biology of the S1P1 receptor -- Chemical and genetic tools to explore S1P biology -- S1P control of endothelial integrity -- Blood, sphingosine-1-phosphate and lymphocyte migration dynamics in the spleen -- Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule -- Sphingosine-1-phosphate and central nervous system -- RORs in autoimmune disease.
520			_aThis volume focuses on the role of sphingosine-1-phosphate (S1P) and its analogs in the induced sequestration of lymphocytes in secondary lymphoid organs or in the microenvironment of tissues involved in infection or autoimmune disease. Initial chapters define the pathways to understand S1P signaling. They cover the organization ofÂ{u0CE9}gnaling systems, the structural biology of the S1P1 receptor, and the chemical and genetic tools that are available and useful to explore this area of research and therapeutics. The later chapters highlight S1P and endothelial integrity, lymphocyte migration in the spleen, and S1P agonist in controlling immunopathologic manifestations of acute respiratory influenza virus infection (in the lung), and its accompanying cytokine storm as well as immunopathologic disease of the central nervous system, including the beginning of treatments in multiple sclerosis.Â{u03EE}e chapter reveals the possible involvement of other lipid molecules, their use for better understanding lipid signaling, and their potential in the modulation of immune responses.
650		7	_2embne _9138404 _aEnfermedades infecciosas
700	1		_aRosen, Hugh _eeditor literario _985211 _0Local
710	2		_aSpringerLink (Online service) _0Local _9106996
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-05879-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12818690 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQR1 .O437 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11547911 _z06-04-17
988			_aEBSPRINGER
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0