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| 003 | ES-MaUEC | ||
| 005 | 20230213141047.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 140422s2014 gw | s |||| 0|eng d | ||
| 020 | _a9783319051345 | ||
| 024 | 7 |
_a10.1007/978-3-319-05134-5 _2doi |
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| 040 |
_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC |
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| 050 | 4 |
_aRC271.G45 _bS275 2014 |
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| 100 | 1 |
_aSarkar, Fazlul H. _eeditor literario _985193 _0Local |
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| 245 | 1 | 0 |
_aMicroRNA Targeted Cancer Therapy _cedited by Fazlul H. Sarkar. |
| 260 |
_aCham, Switzerland _bSpringer International Publishing _c2014 |
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| 300 |
_a1 recurso en línea (X, 351 p.) _b28 ilustraciones, 25 ilustraciones en color |
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| 336 |
_aTexto (visual) _btxt _2rdacontent |
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| 337 |
_aelectrónico _bc _2rdamedia |
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| 338 |
_arecurso electrónico _bcr _2rdacarrier |
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| 505 | 0 | _aPreface -- The therapeutic role of microRNAs in human gliomas -- miRNA expression and functions in glioma and glioma stem cells -- The role of miRNAs in lung cancer drug resistance and targeted therapy -- The Potential Role of MicroRNA-Based Therapy for Lung Cancer Stem Cells -- State of our knowledge on miRNA targeted therapy in Lung Cancer -- miRNA-based Ovarian Cancer Diagnosis and Therapy -- Application of microRNA in the treatment and diagnosis of cervical cancer -- Overcoming Drug Resistance in Colorectal Cancer by microRNAs -- MicroRNAs as novel targets in liver cancer- facing the clinical challenge -- MicroRNA based therapeutic strategies for cancer: Emphasis on advances in renal cell carcinoma -- Modulating microRNA expression for the therapy of pancreatic cancer -- MicroRNA targeted therapy for overcoming drug resistance, reversal of EMT and elimination of cancer stem cells in prostate and pancreatic cancer.-Â{uDBE4}dulation of deregulated miRNAs for targeted therapy in thyroid cancer -- miRNA-targeted therapies in the most prevalent pediatric solid tumors -- Targeting Immune System Through Targeting miRNA For Cancer Therapy.-Â{uDA52}NA regulation of DNA damage repair proteins in cancer cells: interplay of ATM, TRAIL and miRNA -- miRNA regulation of VEGF/VEGFR signaling -- Systems Biology Approaches in the Design of Effective miRNA-Targeted Therapeutics. Index. | |
| 520 | _aSince the discovery of microRNAs (miRNAs) some twenty years ago by Victor Ambros, David Baulcombe and Gary Ruvkun, these three scientists worked to uncover the mystery of miRNA, the small segments of nucleotides that silence genes. While studying the development of the nematode worm, Ambros and Ruvkun discovered miRNA in animals, while Baulcombe discovered it in plants. Since their discovery, it took more than two decade to fully appreciate the value of miRNA in human health and diseases. Emerging evidence suggest that the activation of oncogenes and/or the inactivation of tumor suppressor genes contribute to the development and progression of tumors. The regulation of genes is by far controlled by many transcription factors which are often deregulated during the development and progression of cancer. In addition, emerging evidence clearly suggests that the deregulation of miRNAs or small non-coding RNAs could also regulate the expression of genes, and likewise, miRNA genes are also regulated by transcription factors. The most attractive feature of miRNAs is that one miRNA can regulate many target genes (mRNAs), and thus miRNA targeted therapy is highly promising because multiple genes could be regulated by targeting a single miRNA, which becomes very important for the killing of highly heterogeneous populations of cancer cells within a tumor mass. Therefore, miRNA targeted therapy is an attractive attribute of miRNA research, which is covered through eighteen chapters complied in this book “MicroRNA targeted Cancer therapyâ€{uC821}nd it is hoped that the field of miRNA research will be appreciated through critical reading of these chapters on the cutting-edge research on miRNAs. | ||
| 650 | 7 |
_aCáncer _2embne _9273952 _xAspectos genéticos |
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| 650 | 7 |
_aCáncer _xInvestigación _0comprobar BNE19901364217 _2embne _9182523 |
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| 856 | 4 | 0 |
_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-05134-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid) |
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_a.b12818616 _b10-10-17 _c01-10-14 |
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_2lcc _cLE |
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_aRC271.G45 S275 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11547832 _z06-04-17 |
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| 988 | _aEBOOK, EBSPRINGERrevisando | ||
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