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008			140327s2014 gw | s |||| 0|eng d
020			_a9783319050263
024	7		_a10.1007/978-3-319-05026-3 _2doi
040			_bspa _dES-MaUEC
050		4	_aRC268.5 _bI589 2014
082	0	4	_a614.5999
100	1		_aInuzuka, Hiroyuki. _985188 _0Local
245	1	0	_aSCF and APC E3 Ubiquitin Ligases in Tumorigenesis _cby Hiroyuki Inuzuka, Wenyi Wei.
260			_aCham, Switzerland _bSpringer _c2014
300			_a1 recurso en línea (V, 118 p.) _b11 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aSpringerBriefs in Cancer Research
505	0		_a1. Introduction -- 2. The Fbxw subclass of SCF E3 ubiquitin Ligases -- 3. The FbxL subclass of SCF E3 ubiquitin Ligases -- 4. The Fbxo subclass of SCF E3 ubiquitin Ligases -- 5. APC/Cdc20 and APC/Cdh1 E3 ubiquitin Ligases -- 6. Conclusions and Future Perspectives.
520			_aThis SpringerBrief explores the physiological roles of Skp1-Cullin1-F-box Complex (SCF) and Anaphase Promoting Complex (APC) in normal cells and in tumor formation. These two related, multi-subunit E3 ubiquitin ligase enzymes, APC and SCF are thought to be the major driving forces governing proper cell cycle progression. Defective cell cycle regulation leads to genomic instability and ultimately, cancer development. Selective degradation of key cell cycle regulators by the ubiquitin-proteasome system has been proven to be a major regulatory mechanism for ensuring ordered and coordinated cell cycle progression. The SCF and APC E3 ligases have been characterized to play pivotal roles in regulating the cell cycle progression by timely degrading various critical cell cycle regulators. This Brief reviews recent studies that have shown that deregulation of signaling pathways in which the two ubiquitin ligases are involved causes aberrant cell cycle regulation, in turn leading to tumorigenesis. The text also discusses how SCF and APC may present promising therapeutic targets to treat various cancers.
650		7	_2embne _9146492 _aCarcinogénesis
700	1		_aWei, Wenyi. _985189 _0Local
710	2		_aSpringerLink (Online service) _0Local _9106996
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-05026-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12818598 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aRC268.5 I589 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11547819 _z06-04-17
988			_aEBSPRINGER
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