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008			140612s2014 gw | s |||| 0|eng d
020			_a9783319048437
024	7		_a10.1007/978-3-319-04843-7 _2doi
050		4	_aRC280.B6 _bC87 2014 EB
082	0	4	_a614.5999
245	0	0	_aCurrent Advances in Osteosarcoma _cedited by Eugenie S. Kleinerman, M.D.
260			_aCham, Switzerland _bSpringer International Publishing _c2014
300			_a1 recurso en línea (XII, 359 p.) _b65 ilustraciones, 54 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v804
505	0		_aHistorical Perspective on the Introduction and Use of Chemotherapy for the Treatment of Osteosarcoma -- Wnt Signaling in Osteosarcoma -- Receptor Tyrosine Kinases in Osteosarcoma: Not Just the Usual Suspects -- Understanding the Role of Notch in Osteosarcoma -- Developmental Pathways Highjacked by Osteosarcoma -- MicroRNAs in Osteosarcomagenesis -- RECQ DNA Helicases and Osteosarcoma -- Autophagy in Osteosarcoma -- HER-2 Involvement in Osteosarcoma -- Role of Ezrin in Osteosarcoma Metastasis -- Participation of the Fas/FasL Signaling Pathway and the Lung Microenvironment in the Development of Osteosarcoma Lung Metastases -- Zebrafish as a Model for Human Osteosarcoma -- Using Canine Osteosarcoma as a Model to Assess Efficacy of Novel Therapies: Can Old Dogs Teach Us New Tricks? -- Oncolytic Viruses for Potential Osteosarcoma Therapy -- IL-11Rα: A Novel Target for the Treatment of Osteosarcoma -- Bone-seeking Radiopharmaceuticals as Targeted Agents of Osteosarcoma: Samarium-153-EDTMP and Radium-223 -- Muramyl Tripeptide-phophatidyl Ethanolamine Encapsulated in Lipomes (L-MTP-PE) in the Treatment of Osteosarcoma -- Genetically Modified T-cell Therapy for Osteosarcoma -- Natural Killer Cells for Osteosarcoma
520			_aCurrent Advances in Osteosarcoma summarizes molecular and genetic characteristics, new therapeutic ideas, and biological characteristics that have been uncovered in this field over the past 10 years. Osteosarcoma is an aggressive malignant neoplasm and is the most common histological form of bone cancer. Osteosarcoma accounts for approximately 56% of new bone tumors, making it the most primary malignant bone tumor in children and adolescents. The lungs are the most common site of metastases and once osteosarcoma spreads to the lungs, it is very difficult to treat. At order to improve the outcome of this disease, the biology of osteosarcoma needs to be better understood. There are numerous investigators around the world who have made seminal discoveries about the important molecular pathways and genetic alterations that contribute to the development and metastases of osteosarcoma. Other investigators have proposed novel therapeutic strategies including some based on the molecular and genetic phenotype of the disease. This volume will provide a comprehensive review of these new discoveries in one singular text, which will help move the field forward
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aHuesos _xTumores _9182468 _0comprobar BNE19901362136 _2embne
650		7	_aMieloma múltiple _0comprobar BNE20021387571 _2embne _9160182
700	1		_aKleinerman, M. D., Eugenie S. _eeditor literario _985181 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-04843-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12818549 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b25-05-17 _cm _dz _eu _feng _ggw _h0
945			_aRC280 .B6 C87 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11547765 _z06-04-17
999			_c76236 _d76236 _x1