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003			ES-MaUEC
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007			cr nn 008mamaa
008			140306s2014 gw | s |||| 0|eng d
020			_a9783319046877
024	7		_a10.1007/978-3-319-04687-7 _2doi
040			_aES-MaUEC
050		4	_aRB155 _b.M37 2014 EB
082	0	4	_a611.01816
082	0	4	_a599.935
100	1		_aMasoudi-Nejad, Ali _984784 _0Local
245	1	0	_aGene prioritization : _brationale, methodologies and algorithms _cby Ali Masoudi-Nejad, Alireza Meshkin
260			_aCham _bSpringer International Publishing _c2014
300			_a1 recurso en línea (XII, 66 p.) _b30 ilustraciones, 21 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aSpringerBriefs in Systems Biology _x2193-4746
505	0		_aGene Prioritization Concepts -- Gene Prioritization Rationale -- Evaluations Methods for Gene Prioritization -- Gene Prioritization algorithms -- Successes -- Non-networked-based apoproaches -- Network-based approaches -- Conclusions
520			_aIdentifying causal genes underlying susceptibility to human disease is a problem of primary importance in the post-genomic era and in current biomedical research. Recently, there has been a paradigm shift of such gene-discovery efforts from rare, monogenic conditions to common 2oligogenic3 or 2multifactorial3 conditions such as asthma, diabetes, cancers and neurological disorders. These conditions are referred to as multifactorial because, susceptibility to these diseases is attributed to the combinatorial effects of genetic variation at a number of different genes and their interaction with relevant environmental exposures. The goal of this book is to introduce gene prioritization aspects and the candidate gene prioritization algorithms to give readers a comprehensive view on the subject
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aGenética médica _0comprobar BNE19913258705 _2embne _9144879
650		7	_aEtiología médica _9140556 _0comprobar BNE19900986700 _2embne
700	1		_aMeshkin, Alireza _985179 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-04687-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319046877
907			_a.b12818525 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b24-05-17 _cm _dz _eb _feng _ggw _h0
945			_aRB155 .M37 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11547741 _z06-04-17
999			_c76234 _d76234 _x1