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008			140131s2013 gw | s |||| 0|eng d
020			_a9783319042411
024	7		_a10.1007/978-3-319-04241-1 _2doi
040			_aES-MaUEC
050		4	_aQH434 _b.R67 2013 EB
082	0	4	_a579
100	1		_aRosenberg, Eugene _985176 _0Local
245	1	4	_aThe Hologenome concept : _bhuman, animal and plant microbiota _cby Eugene Rosenberg, Ilana Zilber-Rosenberg
260			_aCham _bSpringer International Publishing _c2013
300			_a1 recurso en línea (XIII, 178 p.)
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aIntroduction: Symbioses and the Hologenome Concept -- Origin of Prokaryotes and Eukaryotes -- Abundance and Diversity of Microbiota -- Microbiotas are Transmitted between Holobiont Generations -- Microbiotas are Part of Holobiont Fitness -- Variation in Holobionts -- Viruses are part of the Holobiont`s Fitness and Evolution -- Evolution of Holobionts -- Pathogens as Symbionts -- Prebiotics, Probiotics, Synbiotics and Phage Therapy -- Epilogue
520			_aGroundbreaking research over the last 10 years has given rise to the hologenome concept of evolution. This concept posits that the holobiont (host plus all of its associated microorganisms) and its hologenome (sum of the genetic information of the host and its symbiotic microorganisms), acting in concert, function as a unique biological entity and therefore as a level of selection in evolution. All animals and plants harbor abundant and diverse microbiota, including viruses. Often the amount of symbiotic microorganisms and their combined genetic information far exceed that of their host. The microbiota with its microbiome, together with the host genome, can be transmitted from one generation to the next and thus propagate the unique properties of the holobiont. The microbial symbionts and the host interact in a cooperative way that affects the health of the holobiont within its environment. Beneficial microbiota protects against pathogens, provides essential nutrients, catabolizes complex polysaccharides, renders harmful chemicals inert, and contributes to the performance of the immune system. In humans and animals, the microbiota also plays a role in behavior. The sum of these cooperative interactions characterizes the holobiont as a unique biological entity. Genetic variation in the hologenome can be brought about by changes in either the host genome or the microbial population genomes (microbiome). Evolution by cooperation can occur by amplifying existing microbes, gaining novel microbiota and by acquiring microbial and viral genes. Under environmental stress, the microbiome can change more rapidly and in response to more processes than the host organism alone and thus influences the evolution of the holobiont. Prebiotics, probiotics, synbiotics and phage therapy are discussed as applied aspects of the hologenome concept
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aGenética microbiana _0comprobar BNE19900988982 _2embne _9140738
650		7	_aGenética _0comprobar BNE19900954839 _2embne _9138044
700	1		_aZilber-Rosenberg, Ilana _985177 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-04241-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319042411
907			_a.b12818495 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b24-05-17 _cm _dz _eb _feng _ggw _h4
945			_aQH434 .R67 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11547716 _z06-04-17
999			_c76231 _d76231 _x1