000			04073nam a2200409 c 4500
001			76226
003			ES-MaUEC
005			20230207040215.0
007			cr nn 008mamaa
008			140224s2014 gw | s |||| 0|eng d
020			_a9783319037257
024	7		_a10.1007/978-3-319-03725-7 _2doi
040			_aES-MaUEC
050		4	_aQP623.5.S63 _bM53 2014 EB
082	0	4	_a614.5999
245	0	0	_aMicroRNAs : _bkey regulators of oncogenesis _cedited by Sadegh Babashah
260			_aCham _bSpringer International Publishing _c2014
300			_a1 recurso en línea (XXVI, 433 p.) _b26 ilustraciones, 21 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aPreface -- Part I MicroRNAs: biology and implications in cancer -- MicroRNAs and cancer: an overview -- Epigenetics and microRNA in cancer -- MicroRNA, diet and cancer chemoprevention -- MicroRNAs and energy metabolism in cancer cells -- MicroRNAs and solid tumors -- MicroRNAs and blood cancers -- MicroRNAs and oncogenic human viruses -- MicroRNAs linking cancer and inflammation: focus on liver cancer -- MicroRNAs and regulatory pathways in tumorigenesis -- MicroRNA-modulated apoptotic and autophagic signaling networks in cancer -- MicroRNAs and cancer drug resistance and drug sensitivity -- The biological roles of microRNAs in cancer stem cells -- Part II MicroRNAs and their clinical implications -- MicroRNAs and clinical implications in cancer -- MicroRNA expression profiling and its clinical impact in breast cancer -- MicroRNAs and their clinical impact on resistance to anticancer treatment -- Nanocarriers and microRNA-based scenarios for cancer therapy -- Challenges and strategies for pulmonary delivery of microRNA-based therapeutics -- Abbreviations -- Index
520			_aAberrant expression and function of microRNAs (miRNAs) in cancer have added a new layer of complexity to the understanding of development and progression of the disease state. It has been demonstrated that miRNAs play a momentous role in oncogenesis via regulating cell proliferation and apoptosis as oncogenes or tumour suppressors. Expression signatures of miRNAs offer exciting opportunities for crafting cutting edge strategies in the diagnosis, prognosis, and therapy of cancer. Since miRNAs can function as either oncogenes or tumor suppressor genes in the tortuous route of oncogenesis, the promise represented by using these small RNAs as therapeutic targets presents new perspectives to the landscape of cancer therapy by either inhibiting or augmenting their activity. This book devotes efforts to provide a broad framework for obtaining an in depth understanding of the state-of-the-art knowledge on abnormalities of miRNAs found to be associated with cancer pathogenesis and possible mechanisms underlying the substantial roles played by miRNAs in cancer development and progression. Also, it intends to pave the way for readers to gain novel insights into using miRNAs as cancer biomarkers and therapeutic platforms
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aARN _0comprobar BNE19913480892 _2embne _9144940
650		7	_9140525 _aÁcidos nucleicos _0comprobar BNE19900986351 _2embne
650		7	_aOncología _0comprobar BNE19900969554 _2embne _9139207
650		7	_aCáncer _xInvestigación _0comprobar BNE19901364217 _2embne _9182523
650		7	_9405049 _aMicrobiología médica _0comprobar BNE19900963008 _2embne
700	1		_aBabashah, Sadegh _eeditor literario _985171 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-03725-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319037257
907			_a.b12818446 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b24-05-17 _cm _dz _eb _feng _ggw _h0
945			_aQP623.5 .S63 M53 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11547662 _z06-04-17
999			_c76226 _d76226 _x1