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003			ES-MaUEC
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007			cr nn 008mamaa
008			140120s2014 gw | s |||| 0|eng d
020			_a9783319029702
024	7		_a10.1007/978-3-319-02970-2 _2doi
040			_aES-MaUEC
050		4	_aQP551 _b.P76 2014 EB
082	0	4	_a610
245	0	0	_aProtein conformational dynamics _cedited by Ke-li Han, Xin Zhang, Ming-jun Yang
260			_aCham _bSpringer International Publishing _c2014
300			_a1 recurso en línea (XII, 488 p.) _b123 ilustraciones, 102 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v805
505	0		_aProtein folding simulations by generalized-ensemble algorithms -- Application of Markov State Models to Simulate Long Timescale Dynamics of Biological Macromolecules -- Understanding protein dynamics using conformational ensembles -- Generative Models of Conformational Dynamics -- Generalized spring tensor models for protein fluctuation dynamics and conformation changes -- The Joys and Perils of Flexible Fitting -- Coarse-Grained Models of the Proteins Backbone Conformational Dynamics -- Simulating protein folding in different environmental conditions -- Simulating the peptide folding kinetic related spectra based on the Markov State Model -- The Dilemma of Conformational Dynamics in Enzyme Catalysis: Perspectives from Theory and Experiment -- Exploiting protein intrinsic flexibility in drug design -- NMR and computational methods in the structural and dynamic characterization of ligand-receptor interactions -- Molecular Dynamics Simulation of Membrane Proteins -- Free-energy landscape of intrinsically disordered proteins investigated by all-atom multicanonical molecular dynamics -- Coordination and control inside simple biomolecular machines -- Multi-state Targeting Machinery Govern the Fidelity and Efficiency of Protein Localization -- Molecular dynamics simulations of F1-ATPase -- Chemosensorial G-proteins-coupled receptors: a perspective from computational methods
520			_aThis book discusses how biological molecules exert their function and regulate biological processes, with a clear focus on how conformational dynamics of proteins are critical inÂ{u4A29}s respect. In the last decade, the advancements in computational biology, nuclear magnetic resonance including paramagnetic relaxation enhancement, and fluorescence-based ensemble/single-molecule techniques have shown that biological molecules (proteins, DNAs and RNAs) fluctuate under equilibrium conditions. The conformational and energetic spaces that these fluctuations explore likely contain active conformations that are critical for their function. More interestingly, these fluctuations can respond actively to external cues, which introduces layers of tight regulation on the biological processes that they dictate. A growing number of studies have suggested that conformational dynamics of proteins govern their role in regulating biological functions, examples of this regulation can be found in signal transduction, molecular recognition, apoptosis, protein / ion / other molecules translocation and gene expression. On the experimental side, the technical advances have offered deep insights into the conformational motions of a number of proteins. These studies greatly enrich our knowledge of the interplay between structure and function. On the theoretical side, novel approaches and detailed computational simulations have provided powerful tools in the study of enzyme catalysis, protein / drug design, protein / ion / other molecule translocation and protein folding/aggregation, to name but a few. This work contains detailed information, not only on the conformational motions of biological systems, but also on the potential governing forces of conformational dynamics (transient interactions, chemical and physical origins, thermodynamic properties). New developments in computational simulations will greatly enhance our understanding of how these molecules function in various biological events
650		7	_aProteínas _0comprobar BNE19900977845 _2embne _9139861
650	0	4	_9668476 _aQuímica bioorgánica _0LocalV
700	1		_aHan, Ke-li _eeditor literario _985167 _0Local
700	1		_aZhang, Xin _eeditor literario _945867
700	1		_aYang, Ming-jun _eeditor literario _985168 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-02970-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319029702
907			_a.b12818410 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQP551 .P76 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11547637 _z06-04-17
988			_aEBOOK, EBSPRINGERrevisando
998			_am _a_alco _a_vill _b24-05-17 _cm _dz _eb _feng _ggw _h0