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001			76199
003			ES-MaUEC
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007			cr nn 008mamaa
008			131108s2014 sz | s |||| 0|eng d
020			_a9783034807265
024	7		_a10.1007/978-3-0348-0726-5 _2doi
040			_aES-MaUEC
050		4	_aQR185.8.T2 _bT59 2014 EB
082	0	4	_a611.01816
245	0	0	_aT Lymphocytes as tools in diagnostics and immunotoxicology _cedited by Stefan F. Martin
260			_aBasel _bSpringer International Publishing _c2014
300			_a1 recurso en línea (VI, 184 p.) _b27 ilustraciones, 21 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aExperientia Supplementum _x1023-294X _v104
505	0		_aThe use of T cells in Hazard Characterization of Chemical and Drug Allergens and integration in testing strategies -- Activation of the TCR complex by peptide-MHC and superantigens -- Activation of the TCR complex by small chemical compounds -- T Cell Responses to Contact Allergens -- Contact hypersensitivity: Quantitative aspects, susceptibility and risk factors -- Tools and methods for identification and analysis of rare antigen-specific T lymphocytes -- Human T cell priming assay. Depletion of peripheral blood lymphocytes in CD25+ cells improves the in vitro detection of weak allergen-specific T cells -- Correlation of contact sensitizer potency with T cell frequency and TCR repertoire diversity -- On the role of co-inhibitory molecules in dendritic cell: T helper cell co-culture assays aimed to detect chemical induced contact allergy -- T cell responses to drugs and drug metabolites -- Hypersensitivity reactions to betalactams
520			_aThis book summarizes the state-of-the art in the development of T cell-based in vitro assays, which offer useful tools for hazard identification, risk assessment and improvement of diagnostics. It will be of interest to scientists, the chemical and pharmaceutical industry, and regulators involved in the replacement of animal testing methods. The identification of hazardous chemicals and drugs is essential to ensuring human health. The ban on animal testing for the cosmetics industry since 2009 and international efforts to reduce and replace animal testing in research and immunotoxicology call for alternative in vitro methods. The most specific immune response to chemicals and drugs that cause allergic contact dermatitis, respiratory disease and adverse drug reactions is the highly antigen-specific T lymphocyte response. Therefore the use of T cells as tools for identifying contact allergens and drugs that may cause health problems is of great interest
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aLinfocitos T _0comprobar BNE19912601605 _2embne _9144344
650		7	_aLinfocitos _9140675 _0comprobar BNE19900988218 _2embne
650		7	_aDiagnóstico molecular _0comprobar BNE20012504786 _2embne _9158916
700	1		_aMartin, Stefan F. _eeditor literario _985136 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-0348-0726-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783034807265
907			_a.b12818173 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b16-05-17 _cm _dz _eb _feng _gsz _h0
945			_aQR185.8 .T2 T59 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i1154739x _z06-04-17
999			_c76199 _d76199 _x1