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003			ES-MaUEC
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007			cr nn 008mamaa
008			130709s2013 sz | s |||| 0|eng d
020			_a9783034806824
024	7		_a10.1007/978-3-0348-0682-4 _2doi
040			_aES-MaUEC
050		4	_aQP601 _b.C37 2013 EB
082	0	4	_a572.6
100	1		_aCastellano, Immacolata _985130
245	1	0	_aGamma-Glutamyl Transpeptidases : _bstructure and function _cby Immacolata Castellano, Antonello Merlino
260			_aBasel _bSpringer International Publishing _c2013
300			_a1 recurso en línea (VIII, 57 p.) _b28 ilustraciones, 18 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aSpringerBriefs in Biochemistry and Molecular Biology _x2211-9353
505	0		_a1 Introduction -- 2 Occurrence, genes and gene expression -- 3 Structure and function of -GTs -- 4 Autoprocessing and reaction mechanism of -GTs -- 5 -GT in bioclinical -- 6 -GTs: biotechnological and biomedical applications -- 7 Conclusions -- References
520			_aGamma-Glutamyl Transpeptidases (-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the -glutamyl amide bond of glutathione to liberate cysteinylglycine. The released -glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). -GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.-GT is upregulated during inflammation and in several human tumors, and it is involved in many physiological disorders related to oxidative stress, such as Parkinson{u2019}s disease and diabetes. Furthermore, this enzyme is used as a marker of liver disease and cancer. This book coverscurrent knowledge about the structure-function relationship of -GTs andgives information aboutapplications of -GTs in different fields ranging from clinical biochemistry to biotechnology and biomedicine
650		7	_aEnzimas _0comprobar BNE19900962355 _2embne _9138640
650	0	4	_9485040 _aIngeniería bioquímica
700	1		_aMerlino, Antonello _985131
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-0348-0682-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783034806824
907			_a.b12818136 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQP601 .C37 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11547352 _z06-04-17
988			_aEBOOK, EBSPRINGERrevisando
998			_am _a_alco _a_vill _b19-05-17 _cm _dz _eb _feng _gsz _h0