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001			76178
003			ES-MaUEC
005			20230202101931.0
007			cr nn 008mamaa
008			121205s2013 xxu| s 000 0|eng d
020			_a9781627031646
024	7		_a10.1007/978-1-62703-164-6 _2doi
050		4	_aRE901.T67 _bA87 2013 EB
082	0	4	_a615
245	0	0	_aAssessing Ocular Toxicology in Laboratory Animals _cedited by Andrea B Weir, Margaret Collins
260			_aTotowa, NJ _bHumana Press _c2013
300			_a1 recurso en línea (XIV, 319 p.) _b120 ilustraciones, 75 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aMolecular and Integrative Toxicology _x2168-4219
505	0		_aComparative Ocular Anatomy in Commonly Used Laboratory Animals -- Assessment of Ocular Toxicity Potential: Basic Theory and Techniques -- Emerging Imaging Technologies for Assessing Ocular Toxicity in Laboratory Animals -- Emerging Electrophysiological Technologies for Assessing Ocular Toxicity in Laboratory Animals -- Toxicologic Pathology of the Eye:Astologic Preparation and Alterations of the Anterior Segment -- Toxicologic Pathology of the Eye: Alterations of the Lens and Posterior Segment -- Nonclinical Regulatory Aspects for Ophthalmic Drugs -- Ocular Toxicity Regulatory Considerations for Non-Drug Food and Drug
520			_aOcular toxicity is routinely assessed in toxicology studies conducted for regulatory purposes.Aular anatomy and physiology and the assessment of ocular toxicity itself can be challenging to scientists involved in the safety assessment of pharmaceuticals, pesticides and other agents. Anatomical and physiological differences between species can impact the nature of ocular effects observed following intended or unintended exposure of ocular tissues to xenobiotics. Ocular Toxicity in Laboratory Animals provides a concise reference addressing ocular anatomy and physiology across species that will enhance the design and interpretation of toxicology studies conducted for regulatory purposes.At book provides an overview of routine and advanced techniques that are used to assess ocular toxicity including slit lamp biomicroscopy, indirect ophthalmoscopy, electrophysiology and imaging methods for the anterior and posterior segments of the eye. Additionally, the book defines the regulatory expectations for pharmaceuticals intended to treat ocular diseases and for other non-pharmaceutical regulated chemicals. With contributions from experts in the field, Ocular Toxicity in Laboratory Animals is an authoritative, accessible guide for toxicologists and other scientists involved in conducting toxicology studies for regulatory purposes and/or reviewing data from such studies
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650	0	7	_aOftalmología _0LocalV _2embne _9139186
700	1		_aWeir, Andrea B. _eeditor literario _985098 _0Local
700	1		_aCollins, Margaret _eeditor literario _985099 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-62703-164-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b1281796x _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b11-05-17 _cm _dz _eu _feng _gxxu _h0
945			_aRE901 .T67 A87 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11547182 _z06-04-17
999			_c76178 _d76178 _x1