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001			76177
003			ES-MaUEC
005			20230207040212.0
007			cr nn 008mamaa
008			120928s2013 xxu| s 000 0|eng d
020			_a9781627031011
024	7		_a10.1007/978-1-62703-101-1 _2doi
050		4	_aRB155.5 _b.M59 2013 EB
082	0	4	_a571.6
245	0	0	_aMitochondrial DNA, Mitochondria, Disease and Stem Cells _cedited by Justin C. St. John
260			_aTotowa, NJ _bHumana Press _c2013
300			_a1 recurso en línea (X, 189 p.) _b21 ilustraciones, 15 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aStem Cell Biology and Regenerative Medicine
505	0		_aClinical Approach to the Diagnosis of Mitochondrial Disease -- Mitochondrial DNA Mutations and Their Effects on Complex I Biogenesis: Implications for Metabolic Disease -- Embryonic Stem Cells: A Signalling Perspective -- From Oocytes and Pluripotent Stem Cells to Fully Differentiated Fates: (Also) A Mitochondrial Odyssey -- From Pluripotency to Differentiation: The Role of mtDNA in Stem Cell Models of Mitochondrial Diseases -- The Role of Mitochondrial DNA in Tumor Cells -- Assisted Reproductive Technologies to Prevent the Transmission of mtDNA from one Generation to the Next
520			_aThis volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring's well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these affect cellular function and lead to the pathology of human mitochondrial disease. It also highlights the importance of the mitochondrial assembly factors and how mutations to these can lead to mitochondrial disease. The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process. It then discusses how diseases like cancer are initiated and regulated by mutations to mitochondrial DNA and dysfunctional mitochondria. Finally, it draws on assisted reproductive technologies to discuss how some of these approaches might be adapted to prevent the transmission of mutant and deleted mtDNA from one generation to the next
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650	0	7	_aCromosomas _0LocalV _2embne _9139992
650		7	_aEnfermedades hereditarias _9140427 _0comprobar BNE19900984988 _2embne
700	1		_aSt. John, Justin C. _eeditor literario _985097 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-62703-101-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12817958 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b11-05-17 _cm _dz _eu _feng _gxxu _h0
945			_aRB155.5 M59 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11547170 _z06-04-17
999			_c76177 _d76177 _x1