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008			100301s2006 xxu| s |||| 0|eng d
020			_a9781592599318
024	7		_a10.1385/1592599311 _2doi
050		4	_aQP364.7 _bP474 2006
082	0	4	_a615.1
100	1		_aPerez, Dianne M. _eeditor. _985081 _0Local
245	1	4	_aThe Adrenergic Receptors : _bIn the 21st Century _cedited by Dianne M. Perez.
260			_aTotowa, NJ _bHumana Press _c2006.
300			_a1 recurso en línea (XII, 404 p.)
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aThe Receptors
505	0		_aHistorical Perspectives -- Adrenergic Receptors -- Structure-Function -- Ligand Binding, Activation, and Agonist Trafficking -- New Signal Transduction Paradigms -- Regulation of the Cellular Localization and Trafficking of the Adrenergic Receptors -- Adrenergic Receptors in Clinical Medicine -- Imaging Adrenergic Receptors and Their Function -- Use of Fluorescent Ligands and Receptors to Visualize Adrenergic Receptors -- Localization of Adrenergic Receptor Subtypes and Transgenic Expression of Fluorescent-Tagged Receptors -- Genetically Altered Mouse Models -- The ?1-Adrenergic Receptors -- The ?2-Adrenergic Receptors -- The ?-Adrenergic Receptors -- Lessons From Overexpressed Mouse Models -- Adrenergic Receptor Signaling Components in Gene Therapy -- Pharmacogenomics -- Genetic, Molecular, and Clinical Characterization of Adrenergic Receptor Polymorphisms -- Microarray Analysis of Novel Adrenergic Receptor Functions -- Summary and Future Endeavors -- Summary and Future Endeavors.
520			_aThe adrenergic receptors control many critical functions of the heart, kidney, brain, and all organs under autonomic control. Today significant opportunities exist for molecular and genetic analysis of their function and signaling pathways. In The Adrenergic Receptors: In the 21st Century, senior scientists who have developed novel molecular approaches describe the state-of-the-art understanding of the structure and function of the adrenergic receptor subtypes, as well as the role played by these receptors in physiological and pathophysiological settings. Topics range from structure-function studies and the imaging of adrenergic receptors to the use of genetically altered mouse models and pharmacogenomics. Many of the methods described can be applied to characterize any receptor of interest. Highlights include a survey of the knockout and overexpressed mouse models, a review of the new ways that adrenergic receptors can signal, and the effects of polymorphisms on both clinical outcomes and potential gene therapy applications. Additional chapters address modern techniques for assessing adrenergic function, such as fluorescent labeling and microarrays, and offer an insightful historical survey of the extraordinary progress made in our understanding of these receptors in the twentieth century. Comprehensive and authoritative, The Adrenergic Receptors: In the 21st Century provides researchers-through its side-by-side comparison of all the adrenergic receptors (a1, a2, and b) and their subtypes-with an excellent survey of the field, including the rationale for how best to design better drugs for control of the heart, blood pressure, and related pathophysiological systems.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBSPRINGER
650		7	_aFarmacia _0LocalV _2embne _9137891
650		7	_aFarmacia _2embne _9137891
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1385/1592599311 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12817843 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _gxxu _h4
945			_aQP364.7 P474 2006 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11547066 _z06-04-17
999			_c76166 _d76166 _x1