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008			140922s2014 xxu| s |||| 0|eng d
020			_a9781493914265
024	7		_a10.1007/978-1-4939-1426-5 _2doi
040			_bspa _dES-MaUEC
050		4	_aQP563.G32 _bE775 2014
082	0	4	_a612.8
100	1		_aErrington, Adam C. _eeditor. _985070 _0Local
245	1	0	_aExtrasynaptic GABAA Receptors _cedited by Adam C. Errington, Giuseppe Di Giovanni, Vincenzo Crunelli.
260			_aNew York _bSpringer _c2014
300			_a1 recurso en línea (IX, 295 p.) _b34 ilustraciones, 18 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aThe Receptors _v27
505	0		_aA brief introduction to extrasynaptic GABAA receptors and â€t̃onicâ€{u01C1}BAA receptor mediated inhibition in physiology and disease -- Extrasynaptic GABAA receptors: subunit composition, distribution, and regulation -- Biophysical properties of recombinant 2- AND Î-́ subunit containing GABAA receptors -- The pharmacology of extrasynaptic GABAA receptors -- Neurosteroids and extrasynaptic GABAA receptors -- Sources of GABA that activate extrasynaptic GABAA receptors -- Modulation of Extrasynaptic GABAA Receptors by G-protein-coupled Receptors -- Extrasynaptic GABAA receptors and tonic inhibition in spinal cord -- The role of peri-synaptic GABA receptors after stroke -- The role of extrasynaptic GABAA receptors in focal epilepsy -- Gain-of-Function of Thalamic Extrasynaptic GABA-A Receptors in Typical Absence Seizures -- GABAergic control of the hypothalamic-pituitary-adrenal (HPA) axis: role of extrasynaptic GABAA receptors -- Tonic GABAA receptor mediated inhibition in Fragile-X Syndrome: A cause of dysfunction or a pathway for a cure?.
520			_aGABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed “tonicâ€{u0A6E}hibition, has been described. Whereas synaptic GABAA receptors underlie classical “phasicâ€{u01C1}BAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.
650		7	_2embne _aAminoácidos _9138424
700	1		_aDi Giovanni, Giuseppe _eeditor literario _985071 _0Local
700	1		_aCrunelli, Vincenzo _eeditor literario _985072 _0Local
710	2		_aSpringerLink (Online service) _0Local _9106996
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4939-1426-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12817788 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQP563.G32 E775 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11547005 _z06-04-17
988			_aEBSPRINGER
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _gxxu _h0