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008			140822s2014 xxu| s |||| 0|eng d
020			_a9781493912278
024	7		_a10.1007/978-1-4939-1227-8 _2doi
040			_bspa _dES-MaUEC
050		4	_aQP114.M48 _bL673 2014
082	0	4	_223
100	1		_aLopaschuk, Gary D. _eeditor. _934130 _0comprobar BNE20021481824
245	1	0	_aCardiac Energy Metabolism in Health and Disease _cedited by Gary D. Lopaschuk, Naranjan S. Dhalla.
260			_aNew York _bSpringer _c2014
300			_a1 recurso en línea (XV, 295 p.) _b54 ilustraciones, 25 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aAdvances in Biochemistry in Health and Disease _v11
505	0		_aPart 1.Â{u3BEE}ntrol of Energy Metabolism -- 1. A Primer on Carbohydrate Metabolism in the Heart -- 2. Lipoproteins: A Source of Cardiac Lipids -- 3. Role of Lipoprotein Lipase in Fatty Acid Delivery to the Heart -- 4. Control of Myocardial Fatty Acid Uptake -- 5. Cardiac Energy Metabolism in Heart Failure Associated with Obesity and Diabetes -- 6. Transcriptional Control of Mitochondrial Biogenesis and Maturation -- 7. Relationship between Substrate Metabolism and Cardiac Efficiency -- 8. Acetylation in the Control of Mitochondrial Metabolism and Integrity -- Part 2. Alteration in Energy Metabolism -- 9. Adrenergic Control of Cardiac Fatty Acid Oxidation in Diabetes -- 10. The Myocardial Creatine Kinase System in the Normal, Ischaemic and Failing Heart -- 11. Fuel Metabolism Plasticity in Pathological Cardiac Hypertrophy and Failure -- 12. Defects in Mitochondrial Oxidative Phosphorylation in Hearts Subjected to Ischemia-Reperfusion Injury -- 13. The Role of AMPK in the Control of Cardiac Hypertrophy -- 14. The Role of Incomplete Fatty Acid Oxidation in the Development of Cardiac Insulin Resistance -- Part 3. Optimization of Energy Metabolism -- 15. Metabolic Therapy for the Ischemic Heart -- 16. Inhibition of Fatty Acid Oxidation to Treat Heart Failure in Patients -- 17. Cardiac Metabolic Protection for the Newborn Heart -- 18. Targeting Transcriptional Control of Fatty Acid Oxidation to Treat Heart Disease.
520			_aThe heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP.The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy, and any change in this energy supply can seriously compromise cardiac function.Â{u0274} has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease.Â{u0274} is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease. Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional, and physiological levels.Â{u0274} also describes how alterations in energy metabolism contribute to the development of heart dysfunction, and how optimization of energy metabolism can be used to treat heart disease.The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics.The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals.
650		7	_2embne _9672862 _aCorazón _xFisiopatología
700	1		_aDhalla, Naranjan S. _eeditor literario _0Local _984616
710	2		_aSpringerLink (Online service) _0Local _9106996
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4939-1227-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12817764 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQP114.M48 L673 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11546980 _z06-04-17
988			_aEBSPRINGER
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