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008			140908s2014 xxu| s |||| 0|eng d
020			_a9781493912216
024	7		_a10.1007/978-1-4939-1221-6 _2doi
040			_cES-MaUEC
050		4	_aQP623.8.P75 _bY464 2014
082	0	4	_a570
100	1		_aYeo, Gene W. _eeditor. _985067 _0Local
245	1	0	_aSystems Biology of RNA Binding Proteins _cedited by Gene W. Yeo.
260			_aNew York _bSpringer _c2014
300			_a1 recurso en línea (X, 468 p.) _b54 ilustraciones, 52 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v825
505	0		_aEncyclopedia of RNA binding protein expression and domain annotations -- RNA localization and RNA binding proteins that control localization -- Genome-wide approaches to studying alternative polyadenylation events and the RBPs that control them -- RNA binding proteins, PRC complex and long ncRNAs -- Gene and genome regulation by piwi proteins -- Engineering Artificial RBP interactions -- Querying functional polymorphisms by high throughput binding and functional assays -- RNA binding protein networks in EMT/MET -- Therapies against diseases associated with RNA processing defects and RNA binding proteins -- Repeat-disorders and the RNA binding proteins implicated in them -- RNA binding proteins in heart development -- Identification of miRNAs and their targets in C elegans -- Splicing code -- Index.
520			_aAfter transcription in the nucleus, RNA binding proteins (RBPs) recognize cis-regulatory RNA elements within pre-mRNA sequence to form mRNA-protein (mRNP) complexes. Similarly to DNA binding proteins such as transcription factors that regulate gene expression by binding to DNA elements in the promoters of genes, RBPs regulate the fate of target RNAs by interacting with specific sequences or RNA secondary structural features within the transcribed RNA molecule. The set of functional RNA elements recognized by RBPs within target RNAs and which control the temporal, functional and spatial dynamics of the target RNA define a putative “mRNP codeâ€{uE814}hese cis-regulatory RNA elements can be found in the 5â€{u086E}d 3â€{u0D6E}translated regions (UTRs), introns, and exons of all protein-coding genes. RNA elements in 5â€{u086E}d 3â€{u0554}Rs are frequently involved in targeting RNA to specific cellular compartments, affecting 3â€{u096E}d formation, controlling RNA stability and regulating mRNA translation. RNA elements in introns and exons are known to function as splicing enhancers or silencers during the splicing process from pre-mRNA to mature mRNA. This book provides case studies of RNA binding proteins that regulate aspects of RNA processing that are important for fundamental understanding of diseases and development. Chapters include systems-level perspectives, mechanistic insights into RNA processing and RNA Binding proteins in genetic variation, development and disease. The content focuses on systems biology and genomics of RNA Binding proteins and their relation to human diseases.
650		7	_2embne _aGenética _9138044
710	2		_aSpringerLink (Online service) _0Local _9106996
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4939-1221-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12817752 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQP623.8.P75 Y464 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11546979 _z06-04-17
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