000			03742nam a22003855i 4500
999			_c76156 _d76156 _x1
001			76156
003			ES-MaUEC
005			20230207040211.0
007			cr nn 008mamaa
008			140904s2014 xxu| s |||| 0|eng d
020			_a9781493912186
024	7		_a10.1007/978-1-4939-1218-6 _2doi
040			_bspa _dES-MaUEC
050		4	_aQP479 _b.M378 2014
082	0	4	_a612.8
100	1		_aMartemyanov, Kirill A. _eeditor. _985065 _0Local
245	1	0	_aG Protein Signaling Mechanisms in the Retina _cedited by Kirill A. Martemyanov, Alapakkam P. Sampath.
260			_aNew York _bSpringer _c2014
300			_a1 recurso en línea (VIII, 198 p.) _b35 ilustraciones, 26 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aSpringer Series in Vision Research _v3
505	0		_a1. Introduction: G-protein Signaling in the Retina -- Part One- Phototransduction in Rods and Cones -- 2. G-protein Deactivation Mechanisms in Vertebrate Phototransduction -- 3. Signaling by Rod and Cone Photoreceptors: Opsin Properties, G-protein Assembly and Mechanisms of Activation -- 4. G-proteinâ€{u59A6}ector Coupling in the Vertebrate Phototransduction Cascade -- Part II- Inner Retinal GPCR Signaling Pathways -- 5. Interdependence among Members of the mGluR6 G-protein Mediated Signalplex of Retinal Depolarizing Bipolar Cells -- 6. Mechanistic Basis for G-protein Function in ON Bipolar Cells -- 7. Modulation of Trpm1 and the mGluR6 cascade in ON Bipolar Cells -- 8. The Role of Dopamine in Fine-tuning Cone- and Rod-driven Vision -- 9. Regulation of Electrical Synaptic Plasticity in the Retina by G-protein Coupled Receptors -- Part III- Signaling by Photosensitive Ganglion Cells -- 10. The Functional Properties of the G-protein-coupled Receptor melanopsin in Intrinsically Photosensitive Retinal Ganglion Cells.
520			_aWe have learned a great deal about the organization and function of GPCR pathways, and the role that they play in vision. The information gained from these studies has provided, and will continue to provide, critical insights to further our understanding of complex GPCR pathways in the central nervous and endocrine systems. In essence, the retina is the first â€õptogeneticallyâ€{uD932}iven circuit with clearly understood physiology. Thus, studying GPCR-driven pathways in the retina will likely guide the interpretation of optogenetic experiments, which are increasingly utilized to study central circuits. Collectively, these signaling pathways allow the retina to represent visual space over a wide range of light intensities and to synchronize its function to the day/night cycle. G protein Signaling Mechanisms in the Retina summarizes our current understanding of the organizational principles of GPCR pathways, using insights derived from the study of the retina. The book highlights several G protein signaling cascades, including phototransduction, ON bipolar cell signaling, dopaminergic pathways, and ipRGC signaling.
650		7	_2embne _9145006 _aRetina
700	1		_aSampath, Alapakkam P _eeditor literario _985066 _0Local
710	2		_aSpringerLink (Online service) _0Local _9106996
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4939-1218-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12817740 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQP479 .M378 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11546967 _z06-04-17
988			_aEBSPRINGER
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _gxxu _h0